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A family of tests to detect misspecifications in the random-effects structure of generalized linear mixed models

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  • Alonso, A.
  • Litière, S.
  • Molenberghs, G.

Abstract

Estimation in generalized linear mixed models for non-Gaussian longitudinal data is often based on maximum likelihood theory, which assumes that the underlying probability model is correctly specified. It is known that the results obtained from these models are not always robust against misspecification of the random-effects structure. Therefore, diagnostic tools for the detection of this misspecification are of the utmost importance. Three diagnostic tests, based on the eigenvalues of the variance-covariance matrices for the fixed-effects parameters estimates, are proposed in the present work. The power and type I error rate of these tests are studied via simulations. A very acceptable performance was observed in many cases, especially for those misspecifications that can have a big impact on the maximum likelihood estimators.

Suggested Citation

  • Alonso, A. & Litière, S. & Molenberghs, G., 2008. "A family of tests to detect misspecifications in the random-effects structure of generalized linear mixed models," Computational Statistics & Data Analysis, Elsevier, vol. 52(9), pages 4474-4486, May.
    • Handle: RePEc:eee:csdana:v:52:y:2008:i:9:p:4474-4486
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    1. Saskia Litière & Ariel Alonso & Geert Molenberghs, 2007. "Type I and Type II Error Under Random-Effects Misspecification in Generalized Linear Mixed Models," Biometrics, The International Biometric Society, vol. 63(4), pages 1038-1044, December.
    2. Agresti, Alan & Caffo, Brian & Ohman-Strickland, Pamela, 2004. "Examples in which misspecification of a random effects distribution reduces efficiency, and possible remedies," Computational Statistics & Data Analysis, Elsevier, vol. 47(3), pages 639-653, October.
    3. White, Halbert, 1982. "Maximum Likelihood Estimation of Misspecified Models," Econometrica, Econometric Society, vol. 50(1), pages 1-25, January.
    4. Ariel Alonso & Helena Geys & Geert Molenberghs & Michael G. Kenward & Tony Vangeneugden, 2004. "Validation of Surrogate Markers in Multiple Randomized Clinical Trials with Repeated Measurements: Canonical Correlation Approach," Biometrics, The International Biometric Society, vol. 60(4), pages 845-853, December.
    5. Rasmus Waagepetersen, 2006. "A Simulation‐based Goodness‐of‐fit Test for Random Effects in Generalized Linear Mixed Models," Scandinavian Journal of Statistics, Danish Society for Theoretical Statistics;Finnish Statistical Society;Norwegian Statistical Association;Swedish Statistical Association, vol. 33(4), pages 721-731, December.
    6. Emmanuel Lesaffre & Bart Spiessens, 2001. "On the effect of the number of quadrature points in a logistic random effects model: an example," Journal of the Royal Statistical Society Series C, Royal Statistical Society, vol. 50(3), pages 325-335.
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    3. Freddy Hernández & Viviana Giampaoli, 2018. "The Impact of Misspecified Random Effect Distribution in a Weibull Regression Mixed Model," Stats, MDPI, vol. 1(1), pages 1-29, May.
    4. Bartolucci, Francesco & Bacci, Silvia & Pigini, Claudia, 2017. "Misspecification test for random effects in generalized linear finite-mixture models for clustered binary and ordered data," Econometrics and Statistics, Elsevier, vol. 3(C), pages 112-131.
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    6. Reza Drikvandi & Geert Verbeke & Geert Molenberghs, 2017. "Diagnosing misspecification of the random-effects distribution in mixed models," Biometrics, The International Biometric Society, vol. 73(1), pages 63-71, March.
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    10. Kuo-Chin Lin & Yi-Ju Chen, 2016. "Goodness-of-fit tests of generalized linear mixed models for repeated ordinal responses," Journal of Applied Statistics, Taylor & Francis Journals, vol. 43(11), pages 2053-2064, August.
    11. Pryseley, Assam & Tchonlafi, Clotaire & Verbeke, Geert & Molenberghs, Geert, 2011. "Estimating negative variance components from Gaussian and non-Gaussian data: A mixed models approach," Computational Statistics & Data Analysis, Elsevier, vol. 55(2), pages 1071-1085, February.
    12. Fabio, Lizandra C. & Paula, Gilberto A. & Castro, Mário de, 2012. "A Poisson mixed model with nonnormal random effect distribution," Computational Statistics & Data Analysis, Elsevier, vol. 56(6), pages 1499-1510.

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