IDEAS home Printed from https://ideas.repec.org/a/eee/chsofr/v165y2022ip2s0960077922010025.html
   My bibliography  Save this article

Economic aspects of the detection of new strains in a multi-strain epidemiological–mathematical model

Author

Listed:
  • Shami, Labib
  • Lazebnik, Teddy

Abstract

Mankind has struggled with pathogens throughout history. In this context, the contribution of vaccines to the continued economic and social prosperity of humanity is enormous, but it is constantly threatened by the development of vaccine-resistant strains of the pathogen. In this study, we investigate the usage of genomic sequencing tests to detect new strains of a pathogen in a multi-strain pandemic scenario using a mathematical–epidemiological–genomic–economic model. Our model provides a theoretical framework to explore the influence of an extensive number of pharmaceutical interventions in a dynamic multi-strain pandemic. Specifically, we show that while a genomic sequence testing policy can be both economically and epidemiologically efficient, a random sample of the population provides sub-optimal results. Moreover, we demonstrate that the optimal policy is sensitive to the social and economic settings of the population, and provide a machine learning based model that offers a solution to these challenges.

Suggested Citation

  • Shami, Labib & Lazebnik, Teddy, 2022. "Economic aspects of the detection of new strains in a multi-strain epidemiological–mathematical model," Chaos, Solitons & Fractals, Elsevier, vol. 165(P2).
    • Handle: RePEc:eee:chsofr:v:165:y:2022:i:p2:s0960077922010025
    DOI: 10.1016/j.chaos.2022.112823
    as

    Download full text from publisher

    File URL: http://www.sciencedirect.com/science/article/pii/S0960077922010025
    Download Restriction: Full text for ScienceDirect subscribers only
    File URL: https://libkey.io/10.1016/j.chaos.2022.112823?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Dirk Kruger & Harald Uhlig & Taojun Xie, 2020. "Macroeconomic Dynamics and Reallocation in an Epidemic," Working Papers 2020-43, Becker Friedman Institute for Research In Economics.
    2. Martin S Eichenbaum & Sergio Rebelo & Mathias Trabandt, 2021. "The Macroeconomics of Epidemics [Economic activity and the spread of viral diseases: Evidence from high frequency data]," Review of Financial Studies, Society for Financial Studies, vol. 34(11), pages 5149-5187.
    3. Daron Acemoglu & Victor Chernozhukov & Iván Werning & Michael D. Whinston, 2021. "Optimal Targeted Lockdowns in a Multigroup SIR Model," American Economic Review: Insights, American Economic Association, vol. 3(4), pages 487-502, December.
    4. David Berger & Kyle Herkenhoff & Chengdai Huang & Simon Mongey, 2022. "Testing and Reopening in an SEIR Model," Review of Economic Dynamics, Elsevier for the Society for Economic Dynamics, vol. 43, pages 1-21, January.
    5. Facundo Piguillem & Liyan Shi, 2022. "Optimal Covid-19 Quarantine and Testing Policies," The Economic Journal, Royal Economic Society, vol. 132(647), pages 2534-2562.
    6. Ned Augenblick & Jonathan T. Kolstad & Ziad Obermeyer & Ao Wang, 2020. "Group Testing in a Pandemic: The Role of Frequent Testing, Correlated Risk, and Machine Learning," NBER Working Papers 27457, National Bureau of Economic Research, Inc.
    7. Yot Teerawattananon & Saudamini Vishwanath Dabak, 2020. "COVID vaccination logistics: five steps to take now," Nature, Nature, vol. 587(7833), pages 194-196, November.
    8. Fernández-Villaverde, Jesús & Jones, Charles I., 2022. "Estimating and simulating a SIRD Model of COVID-19 for many countries, states, and cities," Journal of Economic Dynamics and Control, Elsevier, vol. 140(C).
    9. Luiz Brotherhood & Philipp Kircher & Cezar Santos & Michèle Tertilt, 2020. "An Economic Model of the Covid-19 Epidemic: The Importance of Testing and Age-Specific Policies," CESifo Working Paper Series 8316, CESifo.
    10. Tesfatsion, Leigh S., 2002. "Agent-Based Computational Economics: Growing Economies from the Bottom Up," Staff General Research Papers Archive 5075, Iowa State University, Department of Economics.
    11. V. V. Chari & Rishabh Kirpalani & Christopher Phelan, 2021. "The Hammer and the Scalpel: On the Economics of Indiscriminate versus Targeted Isolation Policies during Pandemics," Review of Economic Dynamics, Elsevier for the Society for Economic Dynamics, vol. 42, pages 1-14, October.
    12. David Berger & Kyle Herkenhoff & Chengdai Huang & Simon Mongey, 2022. "Testing and Reopening in an SEIR Model," Review of Economic Dynamics, Elsevier for the Society for Economic Dynamics, vol. 43, pages 1-21, January.
    13. Farboodi, Maryam & Jarosch, Gregor & Shimer, Robert, 2021. "Internal and external effects of social distancing in a pandemic," Journal of Economic Theory, Elsevier, vol. 196(C).
    14. Eichenbaum, Martin S. & Rebelo, Sergio & Trabandt, Mathias, 2022. "The macroeconomics of testing and quarantining," Journal of Economic Dynamics and Control, Elsevier, vol. 138(C).
    15. Glenn Ellison, 2020. "Implications of Heterogeneous SIR Models for Analyses of COVID-19," NBER Working Papers 27373, National Bureau of Economic Research, Inc.
    16. Peter Horby & Pham Quang Thai & Niel Hens & Nguyen Thi Thu Yen & Le Quynh Mai & Dang Dinh Thoang & Nguyen Manh Linh & Nguyen Thu Huong & Neal Alexander & W John Edmunds & Tran Nhu Duong & Annette Fox , 2011. "Social Contact Patterns in Vietnam and Implications for the Control of Infectious Diseases," PLOS ONE, Public Library of Science, vol. 6(2), pages 1-7, February.
    17. Ioanna Smyrlaki & Martin Ekman & Antonio Lentini & Nuno Rufino de Sousa & Natali Papanicolaou & Martin Vondracek & Johan Aarum & Hamzah Safari & Shaman Muradrasoli & Antonio Gigliotti Rothfuchs & Jan , 2020. "Massive and rapid COVID-19 testing is feasible by extraction-free SARS-CoV-2 RT-PCR," Nature Communications, Nature, vol. 11(1), pages 1-12, December.
    18. Andrew Atkeson & Michael C. Droste & Michael Mina & James H. Stock, 2020. "Economic Benefits of COVID-19 Screening Tests," NBER Working Papers 28031, National Bureau of Economic Research, Inc.
    19. Yoo, Sunbin & Managi, Shunsuke, 2020. "Global mortality benefits of COVID-19 action," Technological Forecasting and Social Change, Elsevier, vol. 160(C).
    20. Xiaowei Chen & Jing Li & Chen Xiao & Peilin Yang, 2021. "Numerical solution and parameter estimation for uncertain SIR model with application to COVID-19," Fuzzy Optimization and Decision Making, Springer, vol. 20(2), pages 189-208, June.
    21. Luyi Yang & Shiliang Cui & Zhongbin Wang, 2022. "Design of Covid‐19 testing queues," Production and Operations Management, Production and Operations Management Society, vol. 31(5), pages 2204-2221, May.
    22. Broome, John, 1978. "Trying to value a life," Journal of Public Economics, Elsevier, vol. 9(1), pages 91-100, February.
    23. Piccirillo, Vinicius, 2021. "Nonlinear control of infection spread based on a deterministic SEIR model," Chaos, Solitons & Fractals, Elsevier, vol. 149(C).
    24. Eduardo Levy Yeyati & Federico Filippini., 2021. "Social and Economic Impact of COVID-19," Department of Economics Working Papers wp_gob_2021_09, Universidad Torcuato Di Tella.
    25. Brotherhood, Luiz & Kircher, Philipp & Santos, Cezar & Tertilt, Michèle, 2020. "An economic model of the Covid-19 epidemic: The importance of testing and age-specific policies," CEPR Discussion Papers 14695, C.E.P.R. Discussion Papers.
    26. Brotherhood, Luiz & Kircher, Philipp & Santos, Cezar & Tertilt, Michèle, 2020. "An economic model of the Covid-19 epidemic: The importance of testing and age-specific policies," CEPR Discussion Papers 14695, C.E.P.R. Discussion Papers.
    27. Duffy, Michael, 2009. "Economies of Size in Production Agriculture," Staff General Research Papers Archive 31282, Iowa State University, Department of Economics.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Lazebnik, Teddy, 2023. "Computational applications of extended SIR models: A review focused on airborne pandemics," Ecological Modelling, Elsevier, vol. 483(C).
    2. Lazebnik, Teddy & Shami, Labib & Bunimovich-Mendrazitsky, Svetlana, 2023. "Intervention policy influence on the effect of epidemiological crisis on industry-level production through input–output networks," Socio-Economic Planning Sciences, Elsevier, vol. 87(PA).

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Dizioli, Allan & Pinheiro, Roberto, 2021. "Information and inequality in the time of a pandemic," Journal of Economic Dynamics and Control, Elsevier, vol. 130(C).
    2. Eichenbaum, Martin S. & Rebelo, Sergio & Trabandt, Mathias, 2022. "The macroeconomics of testing and quarantining," Journal of Economic Dynamics and Control, Elsevier, vol. 138(C).
    3. Guimarães, Luís, 2021. "Antibody tests: They are more important than we thought," Journal of Mathematical Economics, Elsevier, vol. 93(C).
    4. Farboodi, Maryam & Jarosch, Gregor & Shimer, Robert, 2021. "Internal and external effects of social distancing in a pandemic," Journal of Economic Theory, Elsevier, vol. 196(C).
    5. Mitman, Kurt & Hanley, Douglas & Bognanni, Mark & Kolliner, Daniel, 2020. "Economics and Epidemics: Evidence from an Estimated Spatial Econ-SIR Model," CEPR Discussion Papers 15310, C.E.P.R. Discussion Papers.
    6. Sewon Hur, 2023. "The Distributional Effects Of Covid‐19 And Optimal Mitigation Policies," International Economic Review, Department of Economics, University of Pennsylvania and Osaka University Institute of Social and Economic Research Association, vol. 64(1), pages 261-294, February.
    7. Greg Kaplan & Benjamin Moll & Giovanni L. Violante, 2020. "The Great Lockdown and the Big Stimulus: Tracing the Pandemic Possibility Frontier for the U.S," NBER Working Papers 27794, National Bureau of Economic Research, Inc.
    8. Bisin, Alberto & Moro, Andrea, 2022. "Spatial‐SIR with network structure and behavior: Lockdown rules and the Lucas critique," Journal of Economic Behavior & Organization, Elsevier, vol. 198(C), pages 370-388.
    9. David Berger & Kyle Herkenhoff & Chengdai Huang & Simon Mongey, 2022. "Testing and Reopening in an SEIR Model," Review of Economic Dynamics, Elsevier for the Society for Economic Dynamics, vol. 43, pages 1-21, January.
    10. David Berger & Kyle Herkenhoff & Chengdai Huang & Simon Mongey, 2022. "Testing and Reopening in an SEIR Model," Review of Economic Dynamics, Elsevier for the Society for Economic Dynamics, vol. 43, pages 1-21, January.
    11. Timo Boppart & Karl Harmenberg & John Hassler & Per Krusell & Jonna Olsson, 2020. "Integrated Epi-Econ Assessment," NBER Working Papers 28282, National Bureau of Economic Research, Inc.
    12. Yasushi Iwamoto, 2021. "Welfare economics of managing an epidemic: an exposition," The Japanese Economic Review, Springer, vol. 72(4), pages 537-579, October.
    13. Yinon Bar-On & Tatiana Baron & Ofer Cornfeld & Eran Yashiv, 2023. "When to Lock, Not Whom: Managing Epidemics Using Time-Based Restrictions," Review of Economic Dynamics, Elsevier for the Society for Economic Dynamics, vol. 51, pages 292-321, December.
    14. Garriga, Carlos & Manuelli, Rody & Sanghi, Siddhartha, 2022. "Optimal management of an epidemic: Lockdown, vaccine and value of life," Journal of Economic Dynamics and Control, Elsevier, vol. 140(C).
    15. Yinon Bar-On & Tatiana Baron & Ofer Cornfeld & Eran Yashiv, 2023. "When to Lock, Not Whom: Managing Epidemics Using Time-Based Restrictions," Review of Economic Dynamics, Elsevier for the Society for Economic Dynamics, vol. 51, pages 292-321, December.
    16. Janiak, Alexandre & Machado, Caio & Turén, Javier, 2021. "Covid-19 contagion, economic activity and business reopening protocols," Journal of Economic Behavior & Organization, Elsevier, vol. 182(C), pages 264-284.
    17. Yinon Bar-On & Tatiana Baron & Ofer Cornfeld & Eran Yashiv, 2023. "When to Lock, Not Whom: Managing Epidemics Using Time-Based Restrictions," Review of Economic Dynamics, Elsevier for the Society for Economic Dynamics, vol. 51, pages 292-321, December.
    18. Giagheddu, Marta & Papetti, Andrea, 2023. "The macroeconomics of age-varying epidemics," European Economic Review, Elsevier, vol. 151(C).
    19. Daron Acemoglu & Ali Makhdoumi & Azarakhsh Malekian & Asuman Ozdaglar, 2020. "Testing, Voluntary Social Distancing and the Spread of an Infection," NBER Working Papers 27483, National Bureau of Economic Research, Inc.
    20. Ichino, Andrea & Favero, Carlo A. & Rustichini, Aldo, 2020. "Restarting the economy while saving lives under Covid-19," CEPR Discussion Papers 14664, C.E.P.R. Discussion Papers.

    More about this item

    Keywords

    SIR model; Genetic algorithm; Multi-strain pandemic model; Epidemiological–economic modeling; Genomic testing; Dynamical systems;
    All these keywords.

    JEL classification:

    • C61 - Mathematical and Quantitative Methods - - Mathematical Methods; Programming Models; Mathematical and Simulation Modeling - - - Optimization Techniques; Programming Models; Dynamic Analysis
    • C63 - Mathematical and Quantitative Methods - - Mathematical Methods; Programming Models; Mathematical and Simulation Modeling - - - Computational Techniques
    • I18 - Health, Education, and Welfare - - Health - - - Government Policy; Regulation; Public Health

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:eee:chsofr:v:165:y:2022:i:p2:s0960077922010025. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Thayer, Thomas R. (email available below). General contact details of provider: https://www.journals.elsevier.com/chaos-solitons-and-fractals .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.