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Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

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  1. Ning Wang & Chao Liu & Yingjie Li & Dongxue Huang & Xinyue Wu & Xiaorong Kou & Xiye Wang & Qinjie Wu & Changyang Gong, 2023. "A cooperative nano-CRISPR scaffold potentiates immunotherapy via activation of tumour-intrinsic pyroptosis," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
  2. Si-Jia Sun & Xiao-Dong Jiao & Zhi-Gang Chen & Qi Cao & Jia-Hui Zhu & Qi-Rui Shen & Yi Liu & Zhen Zhang & Fang-Fang Xu & Yu Shi & Jie Tong & Shen-Xi Ouyang & Jiang-Tao Fu & Yi Zhao & Jun Ren & Dong-Jie, 2024. "Gasdermin-E-mediated pyroptosis drives immune checkpoint inhibitor-associated myocarditis via cGAS-STING activation," Nature Communications, Nature, vol. 15(1), pages 1-23, December.
  3. Joo-Hui Han & Rajendra Karki & R. K. Subbarao Malireddi & Raghvendra Mall & Roman Sarkar & Bhesh Raj Sharma & Jonathon Klein & Harmut Berns & Harshan Pisharath & Shondra M. Pruett-Miller & Sung-Jin Ba, 2024. "NINJ1 mediates inflammatory cell death, PANoptosis, and lethality during infection conditions and heat stress," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
  4. Fengxia Ma & Laxman Ghimire & Qian Ren & Yuping Fan & Tong Chen & Arumugam Balasubramanian & Alan Hsu & Fei Liu & Hongbo Yu & Xuemei Xie & Rong Xu & Hongbo R. Luo, 2024. "Gasdermin E dictates inflammatory responses by controlling the mode of neutrophil death," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
  5. Wanfeng Xu & Yun Wang & Shuang Cui & Qiuling Zheng & Yanghao Lin & Qingqing Cui & Yuxin Xie & Yuming Zeng & Chuan Zhang & Yujie Li & Xin Jin & Minna Qin & Huiyong Sun & Haiping Hao & Lijuan Cao, 2025. "Methylcobalamin protects against liver failure via engaging gasdermin E," Nature Communications, Nature, vol. 16(1), pages 1-16, December.
  6. Shuo Wang & An Song & Jun Xie & Yuan-Yuan Wang & Wen-Da Wang & Meng-Jie Zhang & Zhi-Zhong Wu & Qi-Chao Yang & Hao Li & Junjie Zhang & Zhi-Jun Sun, 2024. "Fn-OMV potentiates ZBP1-mediated PANoptosis triggered by oncolytic HSV-1 to fuel antitumor immunity," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
  7. Kei-ichiro Arimoto & Sayuri Miyauchi & Ty D. Troutman & Yue Zhang & Mengdan Liu & Samuel A. Stoner & Amanda G. Davis & Jun-Bao Fan & Yi-Jou Huang & Ming Yan & Christopher K. Glass & Dong-Er Zhang, 2023. "Expansion of interferon inducible gene pool via USP18 inhibition promotes cancer cell pyroptosis," Nature Communications, Nature, vol. 14(1), pages 1-22, December.
  8. Lisa D. J. Schiffelers & Yonas M. Tesfamariam & Lea-Marie Jenster & Stefan Diehl & Sophie C. Binder & Sabine Normann & Jonathan Mayr & Steffen Pritzl & Elena Hagelauer & Anja Kopp & Assaf Alon & Matth, 2024. "Antagonistic nanobodies implicate mechanism of GSDMD pore formation and potential therapeutic application," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
  9. Sara Orehek & Taja Železnik Ramuta & Duško Lainšček & Špela Malenšek & Martin Šala & Mojca Benčina & Roman Jerala & Iva Hafner-Bratkovič, 2024. "Cytokine-armed pyroptosis induces antitumor immunity against diverse types of tumors," Nature Communications, Nature, vol. 15(1), pages 1-22, December.
  10. Jiawei Wu & Cong Ding & Chuqing Zhang & Zhimin Xu & Zhenji Deng & Hanmiao Wei & Tingxiang He & Liufen Long & Linglong Tang & Jun Ma & Xiaoyu Liang, 2025. "Methionine metabolite spermidine inhibits tumor pyroptosis by enhancing MYO6-mediated endocytosis," Nature Communications, Nature, vol. 16(1), pages 1-16, December.
  11. Hanhan Ning & Shan Huang & Yang Lei & Renyong Zhi & Han Yan & Jiaxing Jin & Zhenyu Hu & Kaimin Guo & Jinhua Liu & Jie Yang & Zhe Liu & Yi Ba & Xin Gao & Deqing Hu, 2022. "Enhancer decommissioning by MLL4 ablation elicits dsRNA-interferon signaling and GSDMD-mediated pyroptosis to potentiate anti-tumor immunity," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
  12. Boshu Ouyang & Caihua Shan & Shun Shen & Xinnan Dai & Qingwang Chen & Xiaomin Su & Yongbin Cao & Xifeng Qin & Ying He & Siyu Wang & Ruizhe Xu & Ruining Hu & Leming Shi & Tun Lu & Wuli Yang & Shaojun P, 2024. "AI-powered omics-based drug pair discovery for pyroptosis therapy targeting triple-negative breast cancer," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
  13. Zhaoting Li & Fanyi Mo & Yixin Wang & Wen Li & Yu Chen & Jun Liu & Ting-Jing Chen-Mayfield & Quanyin Hu, 2022. "Enhancing Gasdermin-induced tumor pyroptosis through preventing ESCRT-dependent cell membrane repair augments antitumor immune response," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
  14. Chaiheon Lee & Mingyu Park & W. C. Bhashini Wijesinghe & Seungjin Na & Chae Gyu Lee & Eunhye Hwang & Gwangsu Yoon & Jeong Kyeong Lee & Deok-Ho Roh & Yoon Hee Kwon & Jihyeon Yang & Sebastian A. Hughes , 2024. "Oxidative photocatalysis on membranes triggers non-canonical pyroptosis," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
  15. Liang Zhang & An Song & Qi-Chao Yang & Shu-Jin Li & Shuo Wang & Shu-Cheng Wan & Jianwei Sun & Ryan T. K. Kwok & Jacky W. Y. Lam & Hexiang Deng & Ben Zhong Tang & Zhi-Jun Sun, 2023. "Integration of AIEgens into covalent organic frameworks for pyroptosis and ferroptosis primed cancer immunotherapy," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
  16. Zhu, Ligang & Li, Xiang & Xu, Fei & Yin, Zhiyong & Jin, Jun & Liu, Zhilong & Qi, Hong & Shuai, Jianwei, 2022. "Network modeling-based identification of the switching targets between pyroptosis and secondary pyroptosis," Chaos, Solitons & Fractals, Elsevier, vol. 155(C).
  17. Dao-Gong Zhang & Wen-Qian Yu & Jia-Hui Liu & Li-Gang Kong & Na Zhang & Yong-Dong Song & Xiao-Fei Li & Zhao-Min Fan & Ya-Feng Lyu & Na Li & Hai-Bo Wang, 2023. "Serum/glucocorticoid-inducible kinase 1 deficiency induces NLRP3 inflammasome activation and autoinflammation of macrophages in a murine endolymphatic hydrops model," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
  18. Yuanyuan Wei & Beidi Lan & Tao Zheng & Lin Yang & Xiaoxia Zhang & Lele Cheng & Gulinigaer Tuerhongjiang & Zuyi Yuan & Yue Wu, 2023. "GSDME-mediated pyroptosis promotes the progression and associated inflammation of atherosclerosis," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
  19. Xionghui Ding & Hiroto Kambara & Rongxia Guo & Apurva Kanneganti & Maikel Acosta-Zaldívar & Jiajia Li & Fei Liu & Ting Bei & Wanjun Qi & Xuemei Xie & Wenli Han & Ningning Liu & Cunling Zhang & Xiaoyu , 2021. "Inflammasome-mediated GSDMD activation facilitates escape of Candida albicans from macrophages," Nature Communications, Nature, vol. 12(1), pages 1-24, December.
  20. Yuan Lu & Wenbo He & Xin Huang & Yu He & Xiaojuan Gou & Xiaoke Liu & Zhe Hu & Weize Xu & Khaista Rahman & Shan Li & Sheng Hu & Jie Luo & Gang Cao, 2021. "Strategies to package recombinant Adeno-Associated Virus expressing the N-terminal gasdermin domain for tumor treatment," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
  21. Chen Ni & Xiaohan Lou & Xiaohan Yao & Linlin Wang & Jiajia Wan & Xixi Duan & Jialu Liang & Kaili Zhang & Yuanyuan Yang & Li Zhang & Chanjun Sun & Zhenzhen Li & Ming Wang & Linyu Zhu & Dekang Lv & Zhih, 2022. "ZIP1+ fibroblasts protect lung cancer against chemotherapy via connexin-43 mediated intercellular Zn2+ transfer," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
  22. Stefania A. Mari & Kristyna Pluhackova & Joka Pipercevic & Matthew Leipner & Sebastian Hiller & Andreas Engel & Daniel J. Müller, 2022. "Gasdermin-A3 pore formation propagates along variable pathways," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
  23. Sheng-Yan Huang & Sha Gong & Yin Zhao & Ming-Liang Ye & Jun-Yan Li & Qing-Mei He & Han Qiao & Xi-Rong Tan & Jing-Yun Wang & Ye-Lin Liang & Sai-Wei Huang & Shi-Wei He & Ying-Qin Li & Sha Xu & Ying-Qing, 2024. "PJA1-mediated suppression of pyroptosis as a driver of docetaxel resistance in nasopharyngeal carcinoma," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
  24. Xingkai Ju & Jiao Kong & Guohua Qi & Shuping Hou & Xingkang Diao & Shaojun Dong & Yongdong Jin, 2024. "A wearable electrostimulation-augmented ionic-gel photothermal patch doped with MXene for skin tumor treatment," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
  25. Jingsong Ma & Jiabao Zhao & Chensong Zhang & Jinshui Tan & Ao Cheng & Zhuo Niu & Zeyang Lin & Guangchao Pan & Chao Chen & Yang Ding & Mengya Zhong & Yifan Zhuang & Yubo Xiong & Huiwen Zhou & Shengyi Z, 2025. "Cleavage of CAD by caspase-3 determines the cancer cell fate during chemotherapy," Nature Communications, Nature, vol. 16(1), pages 1-21, December.
  26. Jing Lin & Shihui Sun & Kui Zhao & Fei Gao & Renling Wang & Qi Li & Yanlong Zhou & Jing Zhang & Yue Li & Xinyue Wang & Le Du & Shuai Wang & Zi Li & Huijun Lu & Yungang Lan & Deguang Song & Wei Guo & Y, 2023. "Oncolytic Parapoxvirus induces Gasdermin E-mediated pyroptosis and activates antitumor immunity," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
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