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Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions

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  1. Arthur Macha & Filip Liebsch & Emanuel H. W. Bruckisch & Nele Burdina & Imke Stülpnagel & Konrad Benting & Monika Gunkel & Elmar Behrmann & Guenter Schwarz, 2025. "Gephyrin filaments represent the molecular basis of inhibitory postsynaptic densities," Nature Communications, Nature, vol. 16(1), pages 1-14, December.
  2. William E. Arter & Runzhang Qi & Nadia A. Erkamp & Georg Krainer & Kieran Didi & Timothy J. Welsh & Julia Acker & Jonathan Nixon-Abell & Seema Qamar & Jordina Guillén-Boixet & Titus M. Franzmann & Dav, 2022. "Biomolecular condensate phase diagrams with a combinatorial microdroplet platform," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
  3. David Q. P. Reis & Sara Pereira & Ana P. Ramos & Pedro M. Pereira & Leonor Morgado & Joana Calvário & Adriano O. Henriques & Mónica Serrano & Ana S. Pina, 2024. "Catalytic peptide-based coacervates for enhanced function through structural organization and substrate specificity," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
  4. Senhan Xu & Kejun Yin & Xing Xu & Longping Fu & Ronghu Wu, 2025. "O-GlcNAcylation reduces proteome solubility and regulates the formation of biomolecular condensates in human cells," Nature Communications, Nature, vol. 16(1), pages 1-18, December.
  5. Aishwarya Agarwal & Lisha Arora & Sandeep K. Rai & Anamika Avni & Samrat Mukhopadhyay, 2022. "Spatiotemporal modulations in heterotypic condensates of prion and α-synuclein control phase transitions and amyloid conversion," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
  6. Saumyak Mukherjee & Lars V. Schäfer, 2023. "Thermodynamic forces from protein and water govern condensate formation of an intrinsically disordered protein domain," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
  7. Yuri Hong & Saeed Najafi & Thomas Casey & Joan-Emma Shea & Song-I Han & Dong Soo Hwang, 2022. "Hydrophobicity of arginine leads to reentrant liquid-liquid phase separation behaviors of arginine-rich proteins," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
  8. Sejun Yang & Yeonwoo Yu & Seonghyeon Jo & Yehee Lee & Seojin Son & Ki Hoon Lee, 2024. "Calcium ion-triggered liquid-liquid phase separation of silk fibroin and spinning through acidification and shear stress," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
  9. Emanuele Zippo & Dorothee Dormann & Thomas Speck & Lukas S. Stelzl, 2025. "Molecular simulations of enzymatic phosphorylation of disordered proteins and their condensates," Nature Communications, Nature, vol. 16(1), pages 1-16, December.
  10. Simon Alberti & Paolo Arosio & Robert B. Best & Steven Boeynaems & Danfeng Cai & Rosana Collepardo-Guevara & Gregory L. Dignon & Rumiana Dimova & Shana Elbaum-Garfinkle & Nicolas L. Fawzi & Monika Fux, 2025. "Current practices in the study of biomolecular condensates: a community comment," Nature Communications, Nature, vol. 16(1), pages 1-14, December.
  11. Georg Krainer & Kadi L. Saar & William E. Arter & Timothy J. Welsh & Magdalena A. Czekalska & Raphaël P. B. Jacquat & Quentin Peter & Walther C. Traberg & Arvind Pujari & Akhila K. Jayaram & Pavankuma, 2023. "Direct digital sensing of protein biomarkers in solution," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
  12. Andres R. Tejedor & Ignacio Sanchez-Burgos & Maria Estevez-Espinosa & Adiran Garaizar & Rosana Collepardo-Guevara & Jorge Ramirez & Jorge R. Espinosa, 2022. "Protein structural transitions critically transform the network connectivity and viscoelasticity of RNA-binding protein condensates but RNA can prevent it," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
  13. Manisha Poudyal & Komal Patel & Laxmikant Gadhe & Ajay Singh Sawner & Pradeep Kadu & Debalina Datta & Semanti Mukherjee & Soumik Ray & Ambuja Navalkar & Siddhartha Maiti & Debdeep Chatterjee & Jyoti D, 2023. "Intermolecular interactions underlie protein/peptide phase separation irrespective of sequence and structure at crowded milieu," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
  14. Hong Zhang & Huazhang Guo & Danni Li & Yiling Zhang & Shengnan Zhang & Wenyan Kang & Cong Liu & Weidong Le & Liang Wang & Dan Li & Bin Dai, 2024. "Halogen doped graphene quantum dots modulate TDP-43 phase separation and aggregation in the nucleus," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
  15. Tuan Nguyen & Sai Li & Jeremy T-H Chang & John W. Watters & Htet Ng & Adewola Osunsade & Yael David & Shixin Liu, 2022. "Chromatin sequesters pioneer transcription factor Sox2 from exerting force on DNA," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
  16. Jing Ma & Shuai Li & Tengyue Wang & Zhen Tao & Shijie Huang & Ning Lin & Yibing Zhao & Chuanhong Wang & Peijin Li, 2025. "Cooperative condensation of RNA-DIRECTED DNA METHYLATION 16 splicing isoforms enhances heat tolerance in Arabidopsis," Nature Communications, Nature, vol. 16(1), pages 1-16, December.
  17. Hannes Ausserwöger & Ella Csilléry & Daoyuan Qian & Georg Krainer & Timothy J. Welsh & Tomas Sneideris & Titus M. Franzmann & Seema Qamar & Nadia A. Erkamp & Jonathon Nixon-Abell & Mrityunjoy Kar & Pe, 2025. "Quantifying collective interactions in biomolecular phase separation," Nature Communications, Nature, vol. 16(1), pages 1-13, December.
  18. Andrew Z. Lin & Kiersten M. Ruff & Furqan Dar & Ameya Jalihal & Matthew R. King & Jared M. Lalmansingh & Ammon E. Posey & Nadia A. Erkamp & Ian Seim & Amy S. Gladfelter & Rohit V. Pappu, 2023. "Dynamical control enables the formation of demixed biomolecular condensates," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
  19. Kirstin Meyer & Klaus Yserentant & Rasmi Cheloor-Kovilakam & Kiersten M. Ruff & Chan-I Chung & Xiaokun Shu & Bo Huang & Orion D. Weiner, 2025. "YAP charge patterning mediates signal integration through transcriptional co-condensates," Nature Communications, Nature, vol. 16(1), pages 1-16, December.
  20. Ignacio Sanchez-Burgos & Andres R. Tejedor & Alejandro Castro & Alejandro Feito & Rosana Collepardo-Guevara & Jorge R. Espinosa, 2025. "Charged peptides enriched in aromatic residues decelerate condensate ageing driven by cross-β-sheet formation," Nature Communications, Nature, vol. 16(1), pages 1-14, December.
  21. Tomas Sneideris & Nadia A. Erkamp & Hannes Ausserwöger & Kadi L. Saar & Timothy J. Welsh & Daoyuan Qian & Kai Katsuya-Gaviria & Margaret L. L. Y. Johncock & Georg Krainer & Alexander Borodavka & Tuoma, 2023. "Targeting nucleic acid phase transitions as a mechanism of action for antimicrobial peptides," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
  22. Georg Krainer & Raphael P. B. Jacquat & Matthias M. Schneider & Timothy J. Welsh & Jieyuan Fan & Quentin A. E. Peter & Ewa A. Andrzejewska & Greta Šneiderienė & Magdalena A. Czekalska & Hannes Ausserw, 2024. "Single-molecule digital sizing of proteins in solution," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
  23. Hema M. Swasthi & Joseph L. Basalla & Claire E. Dudley & Anthony G. Vecchiarelli & Matthew R. Chapman, 2023. "Cell surface-localized CsgF condensate is a gatekeeper in bacterial curli subunit secretion," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
  24. Daniel C. Carrettiero & Maria C. Almeida & Andrew P. Longhini & Jennifer N. Rauch & Dasol Han & Xuemei Zhang & Saeed Najafi & Jason E. Gestwicki & Kenneth S. Kosik, 2022. "Stress routes clients to the proteasome via a BAG2 ubiquitin-independent degradation condensate," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
  25. Ashish Joshi & Anuja Walimbe & Snehasis Sarkar & Lisha Arora & Gaganpreet Kaur & Prince Jhandai & Dhruba Chatterjee & Indranil Banerjee & Samrat Mukhopadhyay, 2024. "Intermolecular energy migration via homoFRET captures the modulation in the material property of phase-separated biomolecular condensates," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
  26. Avigail Baruch Leshem & Sian Sloan-Dennison & Tlalit Massarano & Shavit Ben-David & Duncan Graham & Karen Faulds & Hugo E. Gottlieb & Jordan H. Chill & Ayala Lampel, 2023. "Biomolecular condensates formed by designer minimalistic peptides," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
  27. Bikash Chandra Swain & Pascale Sarkis & Vanessa Ung & Sabrina Rousseau & Laurent Fernandez & Ani Meltonyan & V. Esperance Aho & Davide Mercadante & Cameron D. Mackereth & Mikayel Aznauryan, 2024. "Disordered regions of human eIF4B orchestrate a dynamic self-association landscape," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
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