IDEAS home Printed from https://ideas.repec.org/p/nbr/nberwo/35005.html

Early-Life Sugar Restrictions Reduce Genetic Disparities in Adult Adiposity

Author

Listed:
  • Tadeja Gracner
  • Claire Boone
  • Patrick Turley
  • Paul Gertler

Abstract

Genetics confer 2–3-fold higher obesity risk through inherited mechanisms affecting appetite and metabolism, with pathways particularly modifiable during the first 1,000 days of life. We leverage the end of UK sugar rationing in September 1953, a sharp discontinuity in early-life sugar exposure by conception date, to examine whether sugar restriction mitigates genetically determined obesity risk using UK Biobank data linking an obesity polygenic index with adiposity phenotypes. Without rationing, high genetic risk individuals had triple the obesity prevalence of low-risk counterparts. Restriction through age two narrowed this disparity by 40%, operating through visceral rather than general adiposity, and was concentrated among high-risk adults with above-median adiposity levels. Early nutritional environments can alter inherited obesity trajectories, pointing to targeted early-life interventions to reduce genetically determined health inequalities.

Suggested Citation

  • Tadeja Gracner & Claire Boone & Patrick Turley & Paul Gertler, 2026. "Early-Life Sugar Restrictions Reduce Genetic Disparities in Adult Adiposity," NBER Working Papers 35005, National Bureau of Economic Research, Inc.
    • Handle: RePEc:nbr:nberwo:35005
    Note: AG EH
    as

    Download full text from publisher

    File URL: http://www.nber.org/papers/w35005.pdf
    Download Restriction: Access to the full text is generally limited to series subscribers, however if the top level domain of the client browser is in a developing country or transition economy free access is provided. More information about subscriptions and free access is available at http://www.nber.org/wwphelp.html. Free access is also available to older working papers.
    ---><---

    As the access to this document is restricted, you may want to

    for a different version of it.

    More about this item

    JEL classification:

    • I1 - Health, Education, and Welfare - - Health

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nbr:nberwo:35005. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: the person in charge (email available below). General contact details of provider: https://edirc.repec.org/data/nberrus.html .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.