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Do GLP-1 Medications Pay for Themselves?

Author

Listed:
  • Coady Wing
  • Sih-Ting Cai
  • Daniel W. Sacks
  • Kosali I. Simon

Abstract

GLP-1 receptor agonists improve treatment for diabetes, obesity, and cardiovascular disease, but their high prices create fiscal pressure for insurers. GLP-1 spending may overstate net costs because health improvements reduce downstream health spending. We use insurance claims to estimate cost offsets for GLP-1s and find no reduction in downstream medical spending through 60 months. Rather, each dollar of GLP-1 spending generates $0.22 (SE 0.066) in additional non-GLP-1 medical spending, largely outpatient care. Offsets are similar across baseline health sub-populations. However, cost offsets for semaglutide—a more effective later generation GLP-1—are smaller and statistically indistinguishable from zero.

Suggested Citation

  • Coady Wing & Sih-Ting Cai & Daniel W. Sacks & Kosali I. Simon, 2026. "Do GLP-1 Medications Pay for Themselves?," NBER Working Papers 34678, National Bureau of Economic Research, Inc.
  • Handle: RePEc:nbr:nberwo:34678
    Note: AG EH
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    Cited by:

    1. Meltem N. Daysal & Camille Fredrickson & Ida Lykke Kristiansen & Mircea Trandafir & Jonathan Zhang & N. Meltem Daysal, 2026. "The Labor Market Impacts of GLP-1s," CESifo Working Paper Series 12810, CESifo.

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    JEL classification:

    • I11 - Health, Education, and Welfare - - Health - - - Analysis of Health Care Markets

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