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Trends in Thrombolytic Use for Ischemic Stroke in the United States


  • Cutler, David M.
  • Rosen, Allison B.
  • Fang, Margaret C.


BACKGROUND: Although recombinant tissue plasminogen activator (tPA) improves outcomes from ischemic stroke, prior studies have found low rates of administration. Recent guidelines and regulatory agencies have advocated for increased tPA administration in appropriate patients, but it is unclear how many patients actually receive tPA. OBJECTIVE: To determine whether national rates of tPA use for ischemic stroke have increased over time. METHODS: We identified all patients with a primary diagnosis of ischemic stroke from years 2001 to 2006 in the National Hospital Discharge Survey (NHDS), a nationally representative sample of inpatient hospitalizations, and searched for procedure codes for intravenous thrombolytic administration. Clinical and demographic factors were obtained from the survey and multivariable logistic regression used to identify independent predictors associated with thrombolytic use. RESULTS: Among the 22,842 patients hospitalized with ischemic stroke, tPA administration rates increased from 0.87% in 2001 to 2.40% in 2006 (P

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  • Cutler, David M. & Rosen, Allison B. & Fang, Margaret C., 2010. "Trends in Thrombolytic Use for Ischemic Stroke in the United States," Scholarly Articles 5343031, Harvard University Department of Economics.
  • Handle: RePEc:hrv:faseco:5343031

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    1. Roth, Alvin E. & Sonmez, Tayfun & Utku Unver, M., 2005. "Pairwise kidney exchange," Journal of Economic Theory, Elsevier, vol. 125(2), pages 151-188, December.
    2. Alvin E. Roth & Tayfun Sönmez & M. Utku Ünver, 2004. "Kidney Exchange," The Quarterly Journal of Economics, Oxford University Press, vol. 119(2), pages 457-488.
    3. Roth, Alvin E. & Sonmez, Tayfun & Unver, Utku & Delmonico, Francis & Saidman, Susan L., 2014. "Utilizing List Exchange and Non-directed Donation through “Chain” Paired Kidney Donations," MPRA Paper 58246, University Library of Munich, Germany.
    4. Berrens, Robert P. & Bohara, Alok K. & Jenkins-Smith, Hank & Silva, Carol & Weimer, David L., 2003. "The Advent of Internet Surveys for Political Research: A Comparison of Telephone and Internet Samples," Political Analysis, Cambridge University Press, vol. 11(01), pages 1-22, December.
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