IDEAS home Printed from https://ideas.repec.org/p/hal/journl/hal-05229534.html
   My bibliography  Save this paper

Ectopic Adipose Tissue in Subsistence Populations with Minimal Coronary Disease, Large Left Atria, and Very Low Rates of Atrial Fibrillation

Author

Listed:
  • Randall C. Thompson

    (Institute of Kansas City, UMKC - University of Missouri [Kansas City] - University of Missouri System)

  • Benjamin C. Trumble

    (ASU - Arizona State University [Tempe])

  • Daniel Cummings

    (Chapman University)

  • Angela Neunuebel

    (Institute of Kansas City)

  • Paul L. Hooper

    (The University of New Mexico [Albuquerque] - NMC - New Mexico Consortium)

  • Samuel Wann

    (Department of Neuroscience, School of Medicine, University of New Mexico, 915 Caminode salud NE, Reginal Heber Fitz Hall 145, Albuquerque, NM 87131, USA.)

  • Adel H. Allam

    (Al-Azhar University [Cairo, Egypt])

  • Frances Neunuebel

    (Institute of Kansas City)

  • Benjamin Gans

    (Institute of Kansas City)

  • Samantha I. King

    (Institute of Kansas City)

  • Edmond Seabright

    (Al-Azhar University [Cairo, Egypt])

  • Caleb Ellicott Finch

    (USC - University of Southern California)

  • Margaret Gatz

    (USC - University of Southern California)

  • Kenneth Buetow

    (USC - University of Southern California)

  • Michael I. Miyamoto

    (Mission Heritage Medical Group, Providence Health, Mission Viejo,)

  • Guido Lombardi

    (UPCH - Universidad Peruana Cayetano Heredia - Peruvian University Cayetano Heredia [Lima, Peru])

  • Linda Sutherland

    (MemorialCare Health Systems, Fountain Valley, California)

  • James Sutherland

    (MemorialCare Health Systems, Fountain Valley, California)

  • Christopher Ward

    (Institute of Kansas City)

  • Madeleine J. Lee

    (Institute of Kansas City)

  • Ashna Mahadev

    (Institute of Kansas City)

  • Daniel Eid Rodriguez

    (Mizzou - University of Missouri [Columbia] - University of Missouri System)

  • David E. Michalik

    (UC - University of California)

  • Chris Rowan

    (University of Nevada [Reno])

  • Tianyu Cao

    (UC - University of California)

  • Jonathan Stieglitz

    (TSE-R - Toulouse School of Economics - UT Capitole - Université Toulouse Capitole - UT - Université de Toulouse - EHESS - École des hautes études en sciences sociales - CNRS - Centre National de la Recherche Scientifique - INRAE - Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement)

  • Cameron M. Quick

    (University of Missouri [St. Louis] - University of Missouri System)

  • Gregory S Thomas

    (MemorialCare Health Systems, Fountain Valley, California)

  • Jagat Narula

    (Institute of Kansas City)

  • Domini Dey

    (Institute of Kansas City)

  • Michael Gurven

    (UC - University of California)

  • Hillard Kaplan

    (TSE-R - Toulouse School of Economics - UT Capitole - Université Toulouse Capitole - UT - Université de Toulouse - EHESS - École des hautes études en sciences sociales - CNRS - Centre National de la Recherche Scientifique - INRAE - Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement)

Abstract

Background Greater deposits of epicardial adipose tissue are associated with atrial fibrillation and coronary disease, but have not been studied in subsistence populations. Methods We performed CT imaging to measure coronary artery and thoracic aortic calcium (CAC, TAC), epicardial fat thickness (EFT), liver density, and left atrial (LA) anteroposterior diameter and, using a deep learning-enabled software program, epicardial and thoracic fat volume (EFV, TFV), in two remote Amerindian subsistence populations with minimal coronary artery calcification and virtually no atrial fibrillation. We compared 893 adult Tsimane (mean age 58.3±10.5 y, 51.6% male), 440 Moseten (55.9±10.4 y, 53.6% male) to 955 U.S. (56.8±10.8 y, 51.6% male) subjects. Results Tsimane and Moseten had 43%-52% lower EFT, EFV, TFV, and 48-92% less CAC and TAC, respectively than the U.S. cohort. Mean liver measurements were 14-22% denser and LA diameters 10-14% larger (≈ 40% larger by volume). For EFV, Tsimane, Moseten, and U.S. cohorts averaged 54.2±25.6, 60.3±35.1, and 106±53.5 cc, respectively (p

Suggested Citation

  • Randall C. Thompson & Benjamin C. Trumble & Daniel Cummings & Angela Neunuebel & Paul L. Hooper & Samuel Wann & Adel H. Allam & Frances Neunuebel & Benjamin Gans & Samantha I. King & Edmond Seabright , 2025. "Ectopic Adipose Tissue in Subsistence Populations with Minimal Coronary Disease, Large Left Atria, and Very Low Rates of Atrial Fibrillation," Post-Print hal-05229534, HAL.
    • Handle: RePEc:hal:journl:hal-05229534
    DOI: 10.1016/j.ajpc.2025.101271
    as

    Download full text from publisher

    To our knowledge, this item is not available for download. To find whether it is available, there are three options:
    1. Check below whether another version of this item is available online.
    2. Check on the provider's web page whether it is in fact available.
    3. Perform a
    for a similarly titled item that would be available.

    More about this item

    Keywords

    ;
    ;
    ;
    ;

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:hal:journl:hal-05229534. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: CCSD (email available below). General contact details of provider: https://hal.archives-ouvertes.fr/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.