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HLA-E*01:03 Allele in Lung Transplant Recipients Correlates with ă Higher Chronic Lung Allograft Dysfunction Occurrence

Author

Listed:
  • Julie Di Cristofaro

    (EFS - Alpes-Méditerranée - Etablissement Français du Sang - Alpes-Méditerranée - Etablissement Français du Sang, ADES - Anthropologie bio-culturelle, Droit, Ethique et Santé - AMU - Aix Marseille Université - EFS ALPES MEDITERRANEE - CNRS - Centre National de la Recherche Scientifique)

  • Mathieu Pelardy
  • Anderson Loundou

    (Unité d'Aide Méthodologique - APHM - Assistance Publique - Hôpitaux de Marseille - CHU Marseille)

  • Agnès Basire

    (ADES - Anthropologie bio-culturelle, Droit, Ethique et Santé - AMU - Aix Marseille Université - EFS ALPES MEDITERRANEE - CNRS - Centre National de la Recherche Scientifique, EFS - Alpes-Méditerranée - Etablissement Français du Sang - Alpes-Méditerranée - Etablissement Français du Sang)

  • Carine Gomez

    (Hôpital Nord [CHU - APHM])

  • Jacques Chiaroni

    (EFS - Alpes-Méditerranée - Etablissement Français du Sang - Alpes-Méditerranée - Etablissement Français du Sang, ADES - Anthropologie bio-culturelle, Droit, Ethique et Santé - AMU - Aix Marseille Université - EFS ALPES MEDITERRANEE - CNRS - Centre National de la Recherche Scientifique)

  • Pascal Thomas

    (Hôpital Nord [CHU - APHM])

  • Martine Reynaud-Gaubert

    (Hôpital Nord [CHU - APHM])

  • Christophe Picard

    (EFS - Alpes-Méditerranée - Etablissement Français du Sang - Alpes-Méditerranée - Etablissement Français du Sang, ADES - Anthropologie bio-culturelle, Droit, Ethique et Santé - AMU - Aix Marseille Université - EFS ALPES MEDITERRANEE - CNRS - Centre National de la Recherche Scientifique)

Abstract

Lung transplantation (LTx) is a valid therapeutic option for selected ă patients with end-stage lung disease. HLA-E seems to play a major role ă in the immune response to different viral infections and to affect ă transplantation outcome, in Hematopoietic Stem Cell Transplantation, for ă example. Two nonsynonymous alleles, HLA-E*01:01 and HLA-E*01: 03, ă have functional differences, involving relative peptide affinity, cell ă surface expression, and potential lytic activity of NK cells. The aim of ă this retrospective study was to determine the impact of these two ă alleles for LTx recipients on anti-HLA alloimmunization risk, overall ă survival, and chronic rejection (CLAD). HLA-E was genotyped in 119 ă recipients who underwent LTx from 1998 to 2010 in a single ă transplantation center. In univariate analysis, both HLA-E homozygous ă states were associated with impaired overall survival compared to ă heterozygous HLA-E alleles (p = 0.01). In multivariate analysis, ă HLA-E*01:03 allele showed increased CLAD occurrence when compared to ă homozygous HLA-E*01:01 status (HR: 3.563 (CI 95%, 1.016-12), p = ă 0.047). HLA-E allele did not affect pathogen infection or the production ă of de novo DSA. This retrospective study shows an uninvestigated, ă deleterious association of HLA-E alleles with LTx and requires ă verification using a larger cohort.

Suggested Citation

  • Julie Di Cristofaro & Mathieu Pelardy & Anderson Loundou & Agnès Basire & Carine Gomez & Jacques Chiaroni & Pascal Thomas & Martine Reynaud-Gaubert & Christophe Picard, 2016. "HLA-E*01:03 Allele in Lung Transplant Recipients Correlates with ă Higher Chronic Lung Allograft Dysfunction Occurrence," Post-Print hal-01482652, HAL.
  • Handle: RePEc:hal:journl:hal-01482652
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