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Resistant depression : potentiation strategies

Author

Listed:
  • Olivier Doumy
  • Djamila Bennabi

    (CAPS - Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093] - UB - Université de Bourgogne - INSERM - Institut National de la Santé et de la Recherche Médicale)

  • Wissam El-Hage

    (Clinique Psychiatrique Universitaire [Tours] - CHRU Tours - Centre Hospitalier Régional Universitaire de Tours, iBraiN - Imaging, Brain & Neuropsychiatry - UT - Université de Tours - INSERM - Institut National de la Santé et de la Recherche Médicale)

  • Najib Allaïli

    (Centre de neuroImagerie de Recherche, ICM - Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute - UPMC - Université Pierre et Marie Curie - Paris 6 - INSERM - Institut National de la Santé et de la Recherche Médicale - CHU Pitié-Salpêtrière [AP-HP] - AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) - SU - Sorbonne Université - CNRS - Centre National de la Recherche Scientifique)

  • Remy Bation
  • Frank Bellivier

    (VariaPsy - U1144 - Variabilité de réponse aux Psychotropes - UPD7 - Université Paris Diderot - Paris 7 - UPD5 - Université Paris Descartes - Paris 5 - INSERM - Institut National de la Santé et de la Recherche Médicale)

  • Jerome Holtzmann
  • Maxime Bubrovszky

    (LNFP - Laboratoire de Neurosciences Fonctionnelles et Pathologies - Université de Lille, Droit et Santé - CNRS - Centre National de la Recherche Scientifique)

  • Vincent Camus

    (UNIROUEN UFR Santé - UNIROUEN - UFR Santé - UNIROUEN - Université de Rouen Normandie - NU - Normandie Université)

  • Thomas Charpeaud

    (Fondation FondaMental [Créteil], CHU Gabriel Montpied [Clermont-Ferrand] - CHU Clermont-Ferrand)

  • Pierre Courvoisier

    (UGA UFRM - Université Grenoble Alpes - UFR Médecine - UGA [2016-2019] - Université Grenoble Alpes [2016-2019])

  • Thierry d'Amato

    (Vulnérabilité à la schizophrénie : des bases neurobiologiques à la thérapeutique - UCBL - Université Claude Bernard Lyon 1 - Université de Lyon - Centre Hospitalier le Vinatier [Bron])

  • Marion Garnier
  • Frederic Haesebaert
  • Thierry Bougerol

    (Clinique Universitaire de Psychiatrie - CHUGA - Centre Hospitalier Universitaire [CHU Grenoble], Service de Psychiatrie - CHUGA - Centre Hospitalier Universitaire [CHU Grenoble])

  • Christophe Lançon

    (Hôpitaux Sud - Département Universitaire de Psychiatrie - [Hôpital Sainte Marguerite - APHM] - AMU - Aix Marseille Université - APHM - Assistance Publique - Hôpitaux de Marseille - Hôpitaux Sud - Hôpital Sainte-Marguerite [CHU - APHM])

  • Fanny Moliere
  • Isabel Nieto
  • Raphaëlle Richieri

    (Laboratoire de santé publique évaluation des systèmes de soins et santé perçue, Hôpitaux Sud - Département Universitaire de Psychiatrie - [Hôpital Sainte Marguerite - APHM] - AMU - Aix Marseille Université - APHM - Assistance Publique - Hôpitaux de Marseille - Hôpitaux Sud - Hôpital Sainte-Marguerite [CHU - APHM])

  • Ghassen Saba

    (INSERM U955, équipe 15 - Service de psychiatrie - AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) - Hôpital Henri Mondor - Hôpital Albert Chenevier - Réseau de coopération scientifique en santé mentale - Fondation FondaMental [Créteil] - IMRB - Institut Mondor de Recherche Biomédicale - INSERM - Institut National de la Santé et de la Recherche Médicale - IFR10 - UPEC UP12 - Université Paris-Est Créteil Val-de-Marne - Paris 12)

  • Philippe Courtet

    (PSNREC - Neuropsychiatrie : recherche épidémiologique et clinique - UM1 - Université Montpellier 1 - INSERM - Institut National de la Santé et de la Recherche Médicale - UM - Université de Montpellier)

  • Guillaume Vaiva

    (Pôle de Psychiatrie - Faculté de Médecine - IFR10 - Groupe hospitalier Henri Mondor-Albert Chenevier)

  • Marion Leboyer

    (IMRB - Institut Mondor de Recherche Biomédicale - INSERM - Institut National de la Santé et de la Recherche Médicale - IFR10 - UPEC UP12 - Université Paris-Est Créteil Val-de-Marne - Paris 12, Fondation FondaMental [Créteil], IINS - Interdisciplinary Institute for Neuroscience [Bordeaux] - UB - Université de Bordeaux - CNRS - Centre National de la Recherche Scientifique)

  • Pierre-Michel Llorca

    (Service de psychiatrie adulte - B - CHU Clermont-Ferrand)

  • Bruno Aouizerate

    (Centre hospitalier Charles Perrens [Bordeaux])

  • Emmanuel Haffen

    (CAPS - Cognition, Action, et Plasticité Sensorimotrice [Dijon - U1093] - UB - Université de Bourgogne - INSERM - Institut National de la Santé et de la Recherche Médicale)

Abstract

Lithium is among the most classically recommended add-on therapeutic ă strategy for the management of depressive patients showing unsuccessful ă response to standard antidepressant medications. ă The effectiveness of the add-on strategy with lithium requires achieving ă plasma levels above 0.5 mEq/L. ă Mood-stabilizing antiepileptic drugs such as carbamazepine, valproate ă derivatives or lamotrigine have not demonstrated conclusive therapeutic ă effects for the management of depressive patients showing unsuccessful ă response to standard antidepressant medications. ă Thyroid hormones are considered among the currently recommended add-on ă therapeutic strategy for the management of depressive patients showing ă unsuccessful response to standard antidepressant medications. ă The effectiveness of the add-on strategy with thyroid hormones requires ă achieving plasma concentration of TSH close to the lower limits at the ă normal range (0.4 mUI/L) or even below it. Second-generation ă antipsychotics such as aripiprazole or quetiapine have consistently ă demonstrated significant therapeutic effects for the management of ă depressive patients showing unsuccessful response to standard ă antidepressant medications. ă Second-generation antipsychotics however require the careful monitoring ă of both cardiovascular and metabolic adverse effects.

Suggested Citation

  • Olivier Doumy & Djamila Bennabi & Wissam El-Hage & Najib Allaïli & Remy Bation & Frank Bellivier & Jerome Holtzmann & Maxime Bubrovszky & Vincent Camus & Thomas Charpeaud & Pierre Courvoisier & Thierr, 2016. "Resistant depression : potentiation strategies," Post-Print hal-01482633, HAL.
    • Handle: RePEc:hal:journl:hal-01482633
    DOI: 10.1016/j.lpm.2016.02.004
    as

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    Keywords

    Quality of Life;

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