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Resistant depression : Switching and combining strategies of ă antidepressant medications
[Dépression résistante : les stratégies de changement et d’association de médicaments antidépresseurs]

Author

Listed:
  • Thomas Charpeaud

    (Service Psychiatrie Adulte [CHU Clermont-Ferrand] - CHU Gabriel Montpied [Clermont-Ferrand] - CHU Clermont-Ferrand - Pôle Psychiatrie Enfant-Adulte [CHU Clermont-Ferrand] - CHU Clermont-Ferrand - CHU Gabriel Montpied [Clermont-Ferrand] - CHU Clermont-Ferrand)

  • Fanny Moliere

    (Département des urgences et post-urgences psychiatriques [CHRU Montpellier] - CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier])

  • Maxime Bubrovszky

    (Service de Psychiatrie [CHRU Lille] - CHRU Lille - Centre Hospitalier Régional Universitaire [CHU Lille] - Hôpital Michel Fontan 1)

  • Frédéric Haesebaert

    (Centre Hospitalier le Vinatier [Bron])

  • Najib Allaïli

    (Service de Psychiatrie et de Médecine Addictologique [GH Saint-Louis-Lariboisière-Widal] - AP-HP - Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal - AP-HP - Assistance publique - Hôpitaux de Paris)

  • Rémy Bation

    (Centre Hospitalier le Vinatier [Bron])

  • Isabel Nieto

    (Service de Psychiatrie et de Médecine Addictologique [GH Saint-Louis-Lariboisière-Widal] - AP-HP - Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal - AP-HP - Assistance publique - Hôpitaux de Paris)

  • Raphaëlle Richieri

    (Pôle Psychiatrie centre [Hôpital de la Conception] - APHM - Assistance Publique - Hôpitaux de Marseille - LA CONCEPTION - Hôpital de la Conception [CHU - APHM])

  • Ghassen Saba

    (Hôpital Albert Chenevier - Groupe Henri Mondor-Albert Chenevier - AP-HP - Assistance publique - Hôpitaux de Paris)

  • Frank Bellivier

    (Service de Psychiatrie et de Médecine Addictologique [GH Saint-Louis-Lariboisière-Widal] - AP-HP - Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal - AP-HP - Assistance publique - Hôpitaux de Paris)

  • Djamila Bennabi

    (Département de psychiatrie [CHRU de Besançon] - CHRU Besançon - Centre Hospitalier Régional Universitaire de Besançon)

  • Jérôme Holtzmann

    (Pôle Psychiatrie et Neurologie [Grenoble] - CHUGA - CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble)

  • Vincent Camus

    (Clinique Psychiatrique Universitaire [CHRU Tours] - CHRU Bretonneau Tours - Centre Hospitalier Régional Universitaire de Tours)

  • Philippe Courtet

    (Département des urgences et post-urgences psychiatriques [CHRU Montpellier] - CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier])

  • Pierre Courvoisier

    (Pôle Psychiatrie et Neurologie [Grenoble] - CHUGA - CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble)

  • Thierry d'Amato

    (Centre Hospitalier le Vinatier [Bron])

  • Olivier Doumy

    (Centre hospitalier Charles Perrens [Bordeaux])

  • Marion Garnier

    (Service Psychiatrie Adulte [CHU Clermont-Ferrand] - CHU Gabriel Montpied [Clermont-Ferrand] - CHU Clermont-Ferrand - Pôle Psychiatrie Enfant-Adulte [CHU Clermont-Ferrand] - CHU Clermont-Ferrand - CHU Gabriel Montpied [Clermont-Ferrand] - CHU Clermont-Ferrand)

  • Thierry Bougerol

    (Pôle Psychiatrie et Neurologie [Grenoble] - CHUGA - CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble)

  • Christophe Lançon

    (Pôle Psychiatrie centre [Hôpital de la Conception] - APHM - Assistance Publique - Hôpitaux de Marseille - LA CONCEPTION - Hôpital de la Conception [CHU - APHM])

  • Emmanuel Haffen

    (Département de psychiatrie [CHRU de Besançon] - CHRU Besançon - Centre Hospitalier Régional Universitaire de Besançon)

  • Marion Leboyer

    (Hôpital Albert Chenevier - Groupe Henri Mondor-Albert Chenevier - AP-HP - Assistance publique - Hôpitaux de Paris)

  • Pierre-Michel Llorca

    (Service Psychiatrie Adulte [CHU Clermont-Ferrand] - CHU Gabriel Montpied [Clermont-Ferrand] - CHU Clermont-Ferrand - Pôle Psychiatrie Enfant-Adulte [CHU Clermont-Ferrand] - CHU Clermont-Ferrand - CHU Gabriel Montpied [Clermont-Ferrand] - CHU Clermont-Ferrand)

  • Guillaume Vaiva

    (Service de Psychiatrie [CHRU Lille] - CHRU Lille - Centre Hospitalier Régional Universitaire [CHU Lille] - Hôpital Michel Fontan 1)

  • Wissam El-Hage

    (Clinique Psychiatrique Universitaire [CHRU Tours] - CHRU Bretonneau Tours - Centre Hospitalier Régional Universitaire de Tours)

  • Bruno Aouizerate

    (Centre hospitalier Charles Perrens [Bordeaux])

Abstract

Switching antidepressant medication may be helpful in depressed patients ă having no benefit from the initial antidepressant treatment. ă Before considering switching strategy, the initial antidepressant ă treatment should produce no therapeutic effect after at least 4 weeks of ă administration at adequate dosage. ă Choosing an antidepressant of pharmacologically distinct profile fails ă to consistently demonstrate a significant superiority in terms of ă effectiveness over the switching to another antidepressant within the ă same pharmacological class. ă Augmenting SSRI/SNRIs with mirtazapine/mianserin has become the most ă recommended strategy of antidepressant combinations. ă Augmenting SSRI with tricyclic drugs is now a less recommended strategy ă of antidepressant combinations given the increased risk for the ă occurrence of pharmacokinetic drug-drug interactions and adverse ă effects.

Suggested Citation

  • Thomas Charpeaud & Fanny Moliere & Maxime Bubrovszky & Frédéric Haesebaert & Najib Allaïli & Rémy Bation & Isabel Nieto & Raphaëlle Richieri & Ghassen Saba & Frank Bellivier & Djamila Bennabi & Jérôme, 2016. "Resistant depression : Switching and combining strategies of ă antidepressant medications [Dépression résistante : les stratégies de changement et d’association de médicaments antidépresseurs]," Post-Print hal-01482632, HAL.
    • Handle: RePEc:hal:journl:hal-01482632
    DOI: 10.1016/j.lpm.2016.02.003
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