IDEAS home Printed from https://ideas.repec.org/p/hal/journl/hal-01482351.html
   My bibliography  Save this paper

The very high cardiovascular risk in heterozygous familial ă hypercholesterolemia: Analysis of 734 French patients

Author

Listed:
  • Sophie Béliard

    (NORT - Nutrition, obésité et risque thrombotique - INRA - Institut National de la Recherche Agronomique - AMU - Aix Marseille Université - INSERM - Institut National de la Santé et de la Recherche Médicale)

  • Aurélie Millier

    (Creativ-Ceutical - Creativ-Ceutical SARL)

  • Valérie Carreau

    (CHU Pitié-Salpêtrière [AP-HP] - AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) - SU - Sorbonne Université, ICAN - Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases - UPMC - Université Pierre et Marie Curie - Paris 6 - AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) - INSERM - Institut National de la Santé et de la Recherche Médicale - CHU Pitié-Salpêtrière [AP-HP] - AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) - SU - Sorbonne Université)

  • Alain Carrié

    (CHU Pitié-Salpêtrière [AP-HP] - AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) - SU - Sorbonne Université)

  • Philippe Moulin

    (Hôpital Louis Pradel [CHU - HCL] - HCL - Hospices Civils de Lyon)

  • Alexandre Fredenrich

    (CHU - Hôpital Pasteur [Nice])

  • Michel Farnier

    (Point médical (Dijon))

  • Gérald Luc

    (CHRU Lille - Centre Hospitalier Régional Universitaire [CHU Lille])

  • David Rosenbaum

    (ICAN - Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases - UPMC - Université Pierre et Marie Curie - Paris 6 - AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) - INSERM - Institut National de la Santé et de la Recherche Médicale - CHU Pitié-Salpêtrière [AP-HP] - AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) - SU - Sorbonne Université)

  • Mondher Toumi

    (AMU - Aix Marseille Université)

  • Eric Bruckert

    (ICAN - Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases - UPMC - Université Pierre et Marie Curie - Paris 6 - AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) - INSERM - Institut National de la Santé et de la Recherche Médicale - CHU Pitié-Salpêtrière [AP-HP] - AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) - SU - Sorbonne Université)

  • D. Angoulvant

    (CHU Tenon [AP-HP] - AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) - SU - Sorbonne Université)

  • F. Boccara

    (Inconnu)

  • V. Durlach

    (Pôle Thoracique Cardiovasculaire et Neurologique - Hôpital Robert Debré - AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP))

  • J. Ferrières

    (LEASP - Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps - UT3 - Université Toulouse III - Paul Sabatier - UT - Université de Toulouse - INSERM - Institut National de la Santé et de la Recherche Médicale)

  • R. Hankard

    (UT - Université de Tours)

  • M. Krempf

    (Hôpital Guillaume et René Laennec - Centre Hospitalier Universitaire de Nantes)

  • J.D. Lalau

    (CHU Amiens-Picardie)

  • F. Paillard

    (Service de cardiologie et maladies vasculaires [Rennes] = Cardiac, Thoracic, and Vascular Surgery [Rennes] - Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou])

  • N. Peretti

    (CarMeN - Cardiovasculaire, métabolisme, diabétologie et nutrition - UCBL - Université Claude Bernard Lyon 1 - Université de Lyon - HCL - Hospices Civils de Lyon - INSERM - Institut National de la Santé et de la Recherche Médicale - INRAE - Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement, HCL - Hospices Civils de Lyon)

  • A. Pradignac

    (Hôpital de Hautepierre [Strasbourg])

  • Y. Pucheu
  • P. Tounian

    (CHU Trousseau [APHP] - AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) - SU - Sorbonne Université, IHU ICAN - Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière] - CHU Pitié-Salpêtrière [AP-HP] - AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) - SU - Sorbonne Université, INSERM - Institut National de la Santé et de la Recherche Médicale, UPMC - Université Pierre et Marie Curie - Paris 6)

  • B. Vergès

    (Service d'Endocrinologie, Diabétologie et Maladies Métaboliques (CHU de Dijon) - CHU Dijon - Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand, LNC - Lipides - Nutrition - Cancer [Dijon - U1231] - UB - Université de Bourgogne - INSERM - Institut National de la Santé et de la Recherche Médicale - AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement)

  • O. Ziegler

    (CHRU Nancy - Centre Hospitalier Régional Universitaire de Nancy)

Abstract

BACKGROUND: Heterozygous familial hypercholesterolemia (heFH) is a ă genetic disease causing high levels of low-density lipoprotein ă cholesterol (LDL-C). Although this population is at high cardiovascular ă (CV) risk, the risk is variable within patients depending on additional ă risk factors. CV disease risk groups have been defined by the Nouvelle ă Societe Francophone d'Atherosclerose (NSFA) and by the National Lipid ă Association recommendations. ă OBJECTIVES: The study aimed to describe a sample of French heFH ă patients, comparing patients at very high risk (VHR) and patients at ă high risk in terms of demographic and clinical characteristics as well ă as biological measurements and disease management. ă METHODS: Cross-sectional retrospective analysis on 734 patients ă hospitalized after 2005 in 5 academic centers. ă RESULTS: When considering NSFA classification, 550 (74.9%) patients ă belonged to the VHR group. Most patients in the VHR group presented more ă than 1 risk factor, the most prevalent ones being Lp(a) > 50 mg/dL and ă smoking. Patients in the VHR group were older (50.6 vs 45.0 years old, P ă =.0002), and presented a higher body mass index (25.5 kg/m(2) vs 23.3 ă kg/m(2), P

Suggested Citation

  • Sophie Béliard & Aurélie Millier & Valérie Carreau & Alain Carrié & Philippe Moulin & Alexandre Fredenrich & Michel Farnier & Gérald Luc & David Rosenbaum & Mondher Toumi & Eric Bruckert & D. Angoulva, 2016. "The very high cardiovascular risk in heterozygous familial ă hypercholesterolemia: Analysis of 734 French patients," Post-Print hal-01482351, HAL.
    • Handle: RePEc:hal:journl:hal-01482351
    DOI: 10.1016/j.jacl.2016.06.007
    as

    Download full text from publisher

    To our knowledge, this item is not available for download. To find whether it is available, there are three options:
    1. Check below whether another version of this item is available online.
    2. Check on the provider's web page whether it is in fact available.
    3. Perform a search for a similarly titled item that would be available.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:hal:journl:hal-01482351. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: CCSD (email available below). General contact details of provider: https://hal.archives-ouvertes.fr/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.