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Randomization Inference for Matched Pairs with Binary Outcomes

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  • Bob Wilson

Abstract

We give an exact randomization-based confidence set for the average treatment effect (ATE) in matched-pair studies with a binary outcome, requiring neither monotonicity nor any distributional assumption beyond the within-pair coin flip. At its core is an analytic solution to the worst-case allocation of attributable effects: two binomial-symmetry lemmas identify the pattern hardest to reject as a single boundary corner, so testing null hypotheses needs no integer program and no numerical search. Inverting the test via binary search yields a prediction set for the attributable effect in O(log S) Binomial tail calculations; the Bonferroni proposition of Rigdon and Hudgens (2015) produces the ATE confidence set at the same computational cost. The same corner extends without further machinery to a sensitivity analysis for matched observational studies under Rosenbaum's $\Gamma$-model. A simple formula for the design sensitivity illuminates when an observational study can hope to provide evidence for an effect.

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  • Bob Wilson, 2026. "Randomization Inference for Matched Pairs with Binary Outcomes," Papers 2609.03227, arXiv.org.
  • Handle: RePEc:arx:papers:2609.03227
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    File URL: https://arxiv.org/pdf/2609.03227
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    1. Aronow, P.M. & Chang, Haoge & Lopatto, Patrick, 2025. "Fast computation of exact confidence intervals for randomized experiments with binary outcomes," Journal of Econometrics, Elsevier, vol. 251(C).
    2. Qingyuan Zhao, 2019. "On Sensitivity Value of Pair-Matched Observational Studies," Journal of the American Statistical Association, Taylor & Francis Journals, vol. 114(526), pages 713-722, April.
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