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Vaginal microbiota impacts of a Lactobacillus crispatus live biotherapeutic and predictors of colonization in randomized controlled trial

Author

Listed:
  • Bloom, Seth M.
  • Symul, Laura

    (Université catholique de Louvain, LIDAM/ISBA, Belgium)

  • Elsherbin, Joseph
  • Xu, Jiawu
  • Hussain, Salina
  • , e.a.

Abstract

Bacterial vaginosis (BV) affects >25% of women worldwide and often recurs after standard-of-care metronidazole (MTZ) treatment. LACTIN-V, a live biotherapeutic product (LBP) containing Lactobacillus crispatus strain CTV-05, significantly reduced recurrent BV in a phase 2b clinical trial, but efficacy was incomplete. Here, we characterize microbiota and immune effects using multi-omics and define correlates of treatment success. By week 12, an L. crispatus-dominant microbiota was achieved in 30% of LBP recipients compared with 9% of placebo recipients (benefit ratio: 3.31; p

Suggested Citation

  • Bloom, Seth M. & Symul, Laura & Elsherbin, Joseph & Xu, Jiawu & Hussain, Salina & , e.a., 2026. "Vaginal microbiota impacts of a Lactobacillus crispatus live biotherapeutic and predictors of colonization in randomized controlled trial," LIDAM Reprints ISBA 2026029, Université catholique de Louvain, Institute of Statistics, Biostatistics and Actuarial Sciences (ISBA).
    • Handle: RePEc:aiz:louvar:2026029
    DOI: https://doi.org/10.1016/j.chom.2026.03.003
    Note: In: Cell Host & Microbe, vol. 34(4), p. 734-750
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