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Computation of Ratios Using Chemical Reactions and DNA Strand Displacements

In: Transactions on Engineering Technologies

Author

Listed:
  • Iuliia Zarubiieva

    (University of Warwick)

  • Joyun Tseng

    (University of Warwick)

  • Vishwesh Kulkarni

    (University of Warwick)

Abstract

Recent researches has focused on nucleic acids as a substrate for designing biomolecular circuits for in situ monitoring and control. A common approach is to express them by a set of idealised abstract chemical reaction networks (ACRNs). Here, we present new results on how abstract chemical reactions, viz., catalysis, annihilation and degradation, can be used to implement circuits that accurately compute ratio of two input signals. The input signals can be either constant-valued scalars or time-varying scalars or polynomials. We also characterise the robustness of our circuits to parameter variations, as would be encountered in wet-lab implementations.

Suggested Citation

  • Iuliia Zarubiieva & Joyun Tseng & Vishwesh Kulkarni, 2019. "Computation of Ratios Using Chemical Reactions and DNA Strand Displacements," Springer Books, in: Sio-Iong Ao & Len Gelman & Haeng Kon Kim (ed.), Transactions on Engineering Technologies, chapter 0, pages 281-295, Springer.
    • Handle: RePEc:spr:sprchp:978-981-32-9531-5_21
    DOI: 10.1007/978-981-32-9531-5_21
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