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Association of IL-6 Gene rs1800796 Polymorphism with Cancer Risk: A Meta-Analysis

In: Data Science and SDGs

Author

Listed:
  • Md. Harun-Or-Roshid

    (University of Rajshahi, Department of Statistics)

  • Md. Borqat Ali

    (University of Rajshahi, Department of Statistics)

  • Jesmin

    (University of Dhaka, Department of Genetic Engineering and Biotechnology)

  • Md. Nurul Haque Mollah

    (University of Rajshahi, Department of Statistics)

Abstract

Interleukin-6 (IL-6) gene polymorphisms are a crucial functional marker in human body. Several genetic association studies reported the significant association between IL-6 gene and various major disease and cancers. In this study, the association of IL-6 gene polymorphism (rs1800796) with cancer risk was investigated through a meta-analysis, which included the larger sample size. To find the association between IL-6 gene (−572 G/C) polymorphism, we extracted the dataset in 27 eligible studies for 24,138 subjects through an efficient searching strategy from PubMed, PubMed central, web of science, google scholar, and other relevant biological literature-based online databases until February 2019. We investigated the association by comparing the allelic and genotypic case–control frequency based on odds ratio with 95% confidence interval and some other statistical tests. According to the results, the rs1800796 SNP significantly associated with increasing risk (CG vs. CC + GG: OR = 1.12, 95% CI = 1.01 – 1.23, p = 0.0288) of overall cancer, particularly with lung, stomach, and prostate cancer as well as for Asian ethnicity. These findings suggest that IL-6 gene polymorphisms may appraise as a genetic biomarker for cancer risks.

Suggested Citation

  • Md. Harun-Or-Roshid & Md. Borqat Ali & Jesmin & Md. Nurul Haque Mollah, 2021. "Association of IL-6 Gene rs1800796 Polymorphism with Cancer Risk: A Meta-Analysis," Springer Books, in: Bikas Kumar Sinha & Md. Nurul Haque Mollah (ed.), Data Science and SDGs, pages 31-43, Springer.
    • Handle: RePEc:spr:sprchp:978-981-16-1919-9_3
    DOI: 10.1007/978-981-16-1919-9_3
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