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Capitum Selectum, Crossover Studies with Continuous Variables: Power Analysis

In: Statistics Applied to Clinical Trials

Author

Listed:
  • Ton J. Cleophas

    (European Interuniversity College of Pharmaceutical Medicine Lyon, Dept Medicine Albert Schweitzer Hospital Dordrecht)

  • Aeilko H. Zwinderman

    (Dept Statistics Academic Hospital Leiden
    European Interuniversity College of Pharmaceutical Medicine Lyon)

  • Toine F. Cleophas

    (Technical University)

Abstract

The crossover design is a sensitive means of determining the efficacy of new drugs because it eliminates between subject-variability. However, when the response in the first period carries on into the second (carryover effects) or when time factors can not be kept constant in a lengthy crossover (time effects), the statistical power of testing may be jeopardized. We recently demonstrated that the crossover design with binary variables is a powerful method in spite of such factors as carryover effects. Power analysis of crossover trials with continuous variables have not been explicitly studied.

Suggested Citation

  • Ton J. Cleophas & Aeilko H. Zwinderman & Toine F. Cleophas, 2000. "Capitum Selectum, Crossover Studies with Continuous Variables: Power Analysis," Springer Books, in: Statistics Applied to Clinical Trials, chapter 0, pages 80-87, Springer.
    • Handle: RePEc:spr:sprchp:978-94-015-9508-7_10
    DOI: 10.1007/978-94-015-9508-7_10
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