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Investigation of Precursor-Product Relationships in Radiotracer Studies

In: Biomathematics and Related Computational Problems

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  • Michael E. Jones

    (Flinders University of South Australia, School of Medicine)

  • Karen Taransky

    (Flinders University of South Australia, School of Medicine)

Abstract

Radiotracer studies are often carried out in situations where pools bearing a precursor-product relationship have yet to be identified. Where the pools of interest are not directly accessible for input, or where there is recirculation of tracer, the problems of defining precursor-product reltionships and of determining the metabolic flux from precursor to product are complex. This is essentially an inverse problem in compartmental analysis, involving data which is not error-free. We adopt the approach of identifying those pools between which a steady-state compartmental precursor-product relationship can be confidently rejected. The approach can be extended to models involving non-compartmental behaviour.

Suggested Citation

  • Michael E. Jones & Karen Taransky, 1988. "Investigation of Precursor-Product Relationships in Radiotracer Studies," Springer Books, in: Luigi M. Ricciardi (ed.), Biomathematics and Related Computational Problems, pages 473-481, Springer.
    • Handle: RePEc:spr:sprchp:978-94-009-2975-3_42
    DOI: 10.1007/978-94-009-2975-3_42
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