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Applications of the Mathematical Model of Immunological Tolerance to Immunoglobulin Suppression and AIDS

In: Evolution and Control in Biological Systems

Author

Listed:
  • T. Hraba

    (Czechoslovak Academy of Sciences, Institute of Molecular Genetics)

  • J. Doležal

    (Czechoslovak Academy of Sciences, Institute of Information Theory and Automation)

Abstract

Experimental data on population dynamics of lymphocytes are most extensive in mice. This species has been the most widely used and the best analysed in immunological research during the last decades. Our mathematical model of immunological tolerance developed on the basis of experimental findings in tolerance induced to human serum albumin in hatched chickens [1] was applied also to tolerance in mice [2,3]. In this paper we will report applications of this model to two other categories of inhibition phenomena. One of them was experimentally induced in mice and the other observed in human infection. (i) The first phenomenon is isotype or idiotype suppression of short duration induced in neonatal mice [4, 5]. This suppression seems to be due to elimination of B cells by antibodies against the respective markers or their surface immunoglobulins. (ii) The other inhibition phenomenon is the depletion of CD4+ lymphocytes in persons infected with the human deficiency virus (HIV), eventually in patients suffering from the acquired immune deficiency syndrome (AIDS).

Suggested Citation

  • T. Hraba & J. Doležal, 1989. "Applications of the Mathematical Model of Immunological Tolerance to Immunoglobulin Suppression and AIDS," Springer Books, in: A. B. Kurzhanski & K. Sigmund (ed.), Evolution and Control in Biological Systems, pages 135-142, Springer.
    • Handle: RePEc:spr:sprchp:978-94-009-2358-4_13
    DOI: 10.1007/978-94-009-2358-4_13
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