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Graphical Models for Clustered Binary and Continuous Responses

In: Advances in Directional and Linear Statistics

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  • Martin T. Wells

    (Cornell University, Department of Statistical Science)

  • Dabao Zhang

Abstract

Graphical models for clustered data mixed with discrete and continuous responses are developed. Discrete responses are assumed to be regulated by some latent continuous variables and particular link functions are used to describe the regulatory mechanisms. Inferential procedures are constructed using the full-information maximum likelihood estimation and observed/empirical Fisher information matrices. Implementation is carried out by stochastic versions of the generalized EM algorithm. As an illustrative application, clustered data from a developmental toxicity study is re-investigated using the directed graphical model and the proposed algorithms. A new interesting directed association between two mixed outcomes reveals. The proposed methods also apply to cross-sectional data with discrete and continuous responses.

Suggested Citation

  • Martin T. Wells & Dabao Zhang, 2011. "Graphical Models for Clustered Binary and Continuous Responses," Springer Books, in: Martin T. Wells & Ashis SenGupta (ed.), Advances in Directional and Linear Statistics, chapter 0, pages 305-321, Springer.
    • Handle: RePEc:spr:sprchp:978-3-7908-2628-9_19
    DOI: 10.1007/978-3-7908-2628-9_19
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