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A Finite State Model for the Control of Adrenal Cortical Steroid Secretion

In: Systems Theory and Biology

Author

Listed:
  • Donald S. Gann

    (Western Reserve University, Departments of Physiology and Surgery
    Case Institute of Technology, Systems Research Center)

  • Lee E. Ostrander

    (Western Reserve University, Departments of Physiology and Surgery
    Case Institute of Technology, Systems Research Center)

  • James D. Schoeffler

    (Western Reserve University, Departments of Physiology and Surgery
    Case Institute of Technology, Systems Research Center)

Abstract

The steroid hormone Cortisol is the principal secretory product of the adrenal cortex in man and the carnivores. Its rate of secretion is primarily under the control of adrenocorticotropic hormone, or ACTH, secreted by the pituitary gland. The release of ACTH by the pituitary is in turn controlled by the hypothalamus by means of a neurohormone, corticotropin-releasing factor, or CRF. From the late 1940’s until early 1960’s there was a controversy about the mode of control of ACTH release and Cortisol secretion. One school based its view on the possibility of suppression of ACTH release and induction of adrenal atrophy by exogenous Cortisol, and suggested that there is closed-loop automatic control of the peripheral concentration of Cortisol in the blood, with stimulation of ACTH release when the Cortisol level of the blood fell, and suppression of that release when the Cortisol level was elevated. Accordingly, a stimulus would increase the load and lower Cortisol concentration. This would lead to increased CRF release from the hypothalamus and thus increased ACTH release from the pituitary.

Suggested Citation

  • Donald S. Gann & Lee E. Ostrander & James D. Schoeffler, 1968. "A Finite State Model for the Control of Adrenal Cortical Steroid Secretion," Springer Books, in: M. D. Mesarović (ed.), Systems Theory and Biology, pages 185-200, Springer.
    • Handle: RePEc:spr:sprchp:978-3-642-88343-9_8
    DOI: 10.1007/978-3-642-88343-9_8
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