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Differentiation in the Cellular Slime Mold

In: Systems Theory and Biology

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  • Barbara E. Wright

    (The John Collins Warren Laboratories of the Huntington Memorial Hospital of Harvard University at the Massachusetts General Hospital)

Abstract

I have been asked to speak about the cellular slime mold as a model system for analyzing the biochemical basis of differentiation. It is a model system by two reasonable and useful definitions. If one usually thinks of differentiation or morphogenesis as something properly experienced only by organisms at least as complicated as a sea urchin, then the lowly slime mold is only a model, which exhibits behavior closely resembling differentiation. In this context, I shall describe many characteristics of the slime mold which are amazingly similar to, and undoubtedly the ancestor of, differentiation in higher organisms. Of course, if one is a firm believer in evolution and comparative biochemistry, he may consider slime mold behavior quite respectable enough to include in his definition of differentiation. In that event, when we study the slime mold we are not looking hopefully at a model system: we are looking at the real thing!

Suggested Citation

  • Barbara E. Wright, 1968. "Differentiation in the Cellular Slime Mold," Springer Books, in: M. D. Mesarović (ed.), Systems Theory and Biology, pages 115-129, Springer.
  • Handle: RePEc:spr:sprchp:978-3-642-88343-9_5
    DOI: 10.1007/978-3-642-88343-9_5
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