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The Relation Between the Gene Network and the Physical Structure of Chromosomes

In: Modeling, Simulation and Optimization of Complex Processes

Author

Listed:
  • Dieter W. Heermann

    (University of Heidelberg, Institute for Theoretical Physics)

  • Manfred Bohn

    (University of Heidelberg, Institute for Theoretical Physics)

  • Philipp M. Diesinger

    (University of Heidelberg, Institute for Theoretical Physics)

Abstract

Human cells contain 46 chromosomes with a total length of about 5 cm beads-ona- string type of nucleosomal fibre, called chromatin. Packaging this into a nucleus of typically 5–20 μm diameter requires extensive compatification. This packaging cannot be random, as considerable evidence has been gathered that chromatin folding is closely related to local genome function. However, the different levels of compactification are ill understood and not easily accessible by experiments.

Suggested Citation

  • Dieter W. Heermann & Manfred Bohn & Philipp M. Diesinger, 2012. "The Relation Between the Gene Network and the Physical Structure of Chromosomes," Springer Books, in: Hans Georg Bock & Xuan Phu Hoang & Rolf Rannacher & Johannes P. Schlöder (ed.), Modeling, Simulation and Optimization of Complex Processes, edition 127, pages 153-167, Springer.
    • Handle: RePEc:spr:sprchp:978-3-642-25707-0_13
    DOI: 10.1007/978-3-642-25707-0_13
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