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Adjusting for Imbalance in Pre-Vaccination State

In: Statistics in Clinical Vaccine Trials

Author

Listed:
  • Jozef Nauta

    (Global Statistics, Solvay Pharmaceuticals)

Abstract

For some infectious diseases, pre-vaccination antibody levels are not zero. Not all vaccines offer life-long protection, and a number of diseases require re-vaccinations throughout life. Antibody levels prior to re-vaccination with, for example, a tetanus, a diphtheria, a pertussis or a tick borne encephalitis vaccine will often not be zero. If pre-vaccination (baseline) antibody levels are not zero, then the post-vaccination values do not only express the immune responses to the vaccination, but also the subjects’ pre-vaccination state. This can complicate the interpretation of a difference in post-vaccination antibody values between vaccine groups. If there is imbalance in pre-vaccination state, i.e., if there is a difference in baseline antibody values between groups, then part of the post-vaccination difference can be explained by the pre-vaccination difference.

Suggested Citation

  • Jozef Nauta, 2011. "Adjusting for Imbalance in Pre-Vaccination State," Springer Books, in: Statistics in Clinical Vaccine Trials, chapter 0, pages 57-65, Springer.
    • Handle: RePEc:spr:sprchp:978-3-642-14691-6_5
    DOI: 10.1007/978-3-642-14691-6_5
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