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Humoral and Cellular Immunity

In: Statistics in Clinical Vaccine Trials

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  • Jozef Nauta

    (Global Statistics, Solvay Pharmaceuticals)

Abstract

When the adaptive immune system is activated by the innate immune system, the humoral immune response (also: antibody-mediated immune response) triggers specific B cells to develop into plasma cells. These plasma cells then secrete large amounts of antibodies. Antibodies circulate in the lymph and the blood streams. (Hence the name: humoral immunity. Humoral comes from the Greek chymos, a key concept in ancient Greek medicine. In this view, people were made out of four fluids: blood, black bile, yellow bile and mucus (phlegma). Being healthy meant that the four humors were balanced. Having too much of a humor meant unbalance resulting in illness.) The more general term for antibody is immunoglobulin, a group of proteins. There are five different antibody classes: IgG, IgM, IgA, IgE and IgD.

Suggested Citation

  • Jozef Nauta, 2011. "Humoral and Cellular Immunity," Springer Books, in: Statistics in Clinical Vaccine Trials, chapter 0, pages 13-17, Springer.
    • Handle: RePEc:spr:sprchp:978-3-642-14691-6_2
    DOI: 10.1007/978-3-642-14691-6_2
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