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A Singular Value Based Probability Algorithm for Protein Cleavage

In: From Nano to Space

Author

Listed:
  • T. Stolte

    (Technische Universität München, M2 — Zentrum Mathematik)

  • P. Rentrop

    (Technische Universität München, M2 — Zentrum Mathematik)

Abstract

Protein degradation by the proteasome is one of the key steps in cell biology and in immune biology. For degradation a mathematical model can be based on a binomial distribution, where the wanted cleavage probabilities are characterized by a minimization problem. The proposed method analyzes the singular values of the Jacobian, thus giving a significant parameter reduction. The computation time is 50 fold reduced compared to the unreduced model, which in practice means hours instead of days for a run. The implementation is based on MATLAB.

Suggested Citation

  • T. Stolte & P. Rentrop, 2008. "A Singular Value Based Probability Algorithm for Protein Cleavage," Springer Books, in: Michael H. Breitner & Georg Denk & Peter Rentrop (ed.), From Nano to Space, pages 99-110, Springer.
    • Handle: RePEc:spr:sprchp:978-3-540-74238-8_9
    DOI: 10.1007/978-3-540-74238-8_9
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