IDEAS home Printed from https://ideas.repec.org/h/spr/sprchp/978-3-540-28091-0_50.html
   My bibliography  Save this book chapter

Experiment and Simulation of Electrospray Particle-Flows for Controlled Release of Drugs

In: Traffic and Granular Flow ’03

Author

Listed:
  • J.C.M. Marijnissen

    (TU Delft, Particle Technology, DelftChemTech)

  • T. Ciach

    (Warsaw University of Technology, Faculty of Chemical and Process Engineering)

  • M.-K. Müller

    (TU Delft, Particle Technology, DelftChemTech)

  • T. Winkels

    (TU Delft, Particle Technology, DelftChemTech)

  • K.B. Geerse

    (TU Delft, Particle Technology, DelftChemTech
    PURAC division)

  • A. Schmidt-Ott

    (TU Delft, Particle Technology, DelftChemTech)

  • S. Luding

    (TU Delft, Particle Technology, DelftChemTech)

Abstract

Summary Electro HydroDynamic Atomisation (EHDA) disperses a liquid into small, highly charged droplets. We show that this method can be used to produce particles that release a drug at a desired rate. This is done by spraying a solution of bio-degradable polymers and an enzyme, which represents the effective drug. The release rate can be varied by modification of the polymer matrix. It is further demonstrated that the enzyme fully retains its functionality in the EHDA process. Practical use of this technique for medicine production requires a scaled-up design, which must be based on an adequate model of the particle flow in the charged droplet spray plume. As a step in this direction, the most important result is a scale-up relation that allows simulations of an experimental spray with millions of particles, using only a few thousand model particles. The experimental spray is examined with a Phase Doppler Particle Analyser (PDPA) set-up, and the resulting density and velocity profiles are compared to the numerical results. There is a qualitative agreement between experiment and model.

Suggested Citation

  • J.C.M. Marijnissen & T. Ciach & M.-K. Müller & T. Winkels & K.B. Geerse & A. Schmidt-Ott & S. Luding, 2005. "Experiment and Simulation of Electrospray Particle-Flows for Controlled Release of Drugs," Springer Books, in: Serge P. Hoogendoorn & Stefan Luding & Piet H. L. Bovy & Michael Schreckenberg & Dietrich E. Wolf (ed.), Traffic and Granular Flow ’03, pages 513-520, Springer.
    • Handle: RePEc:spr:sprchp:978-3-540-28091-0_50
    DOI: 10.1007/3-540-28091-X_50
    as

    Download full text from publisher

    To our knowledge, this item is not available for download. To find whether it is available, there are three options:
    1. Check below whether another version of this item is available online.
    2. Check on the provider's web page whether it is in fact available.
    3. Perform a
    for a similarly titled item that would be available.

    More about this item

    Keywords

    ;
    ;
    ;
    ;
    ;

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:spr:sprchp:978-3-540-28091-0_50. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.springer.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.