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Variance Control Procedures

In: Principles and Practice of Clinical Trials

Author

Listed:
  • Heidi L. Weiss

    (Markey Cancer Center, University of Kentucky, Biostatistics and Bioinformatics Shared Resource Facility)

  • Jianrong Wu

    (Markey Cancer Center, University of Kentucky, Biostatistics and Bioinformatics Shared Resource Facility)

  • Katrina Epnere

    (WCG Statistics Collaborative)

  • O. Dale Williams

    (University of North Carolina, Department of Biostatistics
    University of Alabama at Birmingham, Department of Medicine)

Abstract

This chapter covers the concepts of variance and sources of variation for clinical trial data. Common metrics to quantify the extent of variability in relation to the mean are introduced as are clinical trial design techniques and statistical analysis methods to control and reduce this variation. The uses of variance as a data quality assessment tool in large-scale, long-term multicenter clinical trials are highlighted.

Suggested Citation

  • Heidi L. Weiss & Jianrong Wu & Katrina Epnere & O. Dale Williams, 2022. "Variance Control Procedures," Springer Books, in: Steven Piantadosi & Curtis L. Meinert (ed.), Principles and Practice of Clinical Trials, chapter 46, pages 833-841, Springer.
    • Handle: RePEc:spr:sprchp:978-3-319-52636-2_218
    DOI: 10.1007/978-3-319-52636-2_218
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