IDEAS home Printed from https://ideas.repec.org/h/spr/sprchp/978-3-319-52636-2_163.html
   My bibliography  Save this book chapter

Fraud in Clinical Trials

In: Principles and Practice of Clinical Trials

Author

Listed:
  • Stephen L. George

    (Duke University School of Medicine, Department of Biostatistics and Bioinformatics, Basic Science Division)

  • Marc Buyse

    (International Drug Development Institute (IDDI) Inc.
    University of Hasselt, CluePoints S.A., Louvain-la-Neuve, Belgium and I-BioStat
    Hasselt University, Interuniversity Institute for Biostatistics and Statistical Bioinformatics (I-BioStat))

  • Steven Piantadosi

    (Brigham and Women’s Hospital, Harvard Medical School, Department of Surgery, Division of Surgical Oncology)

Abstract

Several high-profile cases of fabrication or falsification of data have occurred in clinical trials in recent years. The number of such reported cases is quite low, given the large number of clinical trials conducted worldwide. Although this suggests that the prevalence of fraud is very low, reliable evidence on prevalence is lacking. Regardless of the true prevalence, fraud is damaging to the public trust in the clinical trial process and can put patients at risk. This chapter summarizes some prominent examples of detected fraud in clinical trials, the existing evidence on prevalence, contributing predisposing factors and statistical techniques for detection of fraud.

Suggested Citation

  • Stephen L. George & Marc Buyse & Steven Piantadosi, 2022. "Fraud in Clinical Trials," Springer Books, in: Steven Piantadosi & Curtis L. Meinert (ed.), Principles and Practice of Clinical Trials, chapter 118, pages 2319-2337, Springer.
    • Handle: RePEc:spr:sprchp:978-3-319-52636-2_163
    DOI: 10.1007/978-3-319-52636-2_163
    as

    Download full text from publisher

    To our knowledge, this item is not available for download. To find whether it is available, there are three options:
    1. Check below whether another version of this item is available online.
    2. Check on the provider's web page whether it is in fact available.
    3. Perform a
    for a similarly titled item that would be available.

    More about this item

    Keywords

    ;
    ;
    ;
    ;
    ;
    ;
    ;

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:spr:sprchp:978-3-319-52636-2_163. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.springer.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.