IDEAS home Printed from https://ideas.repec.org/h/spr/sprchp/978-3-319-52636-2_114.html
   My bibliography  Save this book chapter

Estimation and Hypothesis Testing

In: Principles and Practice of Clinical Trials

Author

Listed:
  • Pamela A. Shaw

    (University of Pennsylvania Perelman School of Medicine)

  • Michael A. Proschan

    (National Institute of Allergy and Infectious Diseases)

Abstract

This chapter presents basic elements of parameter estimation and hypothesis testing. The reader will learn how to form confidence intervals for the mean, and more generally, how to calculate confidence intervals for the one parameter setting and for the difference between two groups. Principles of hypothesis testing are detailed, including the choice of the null and alternative hypotheses, the significance level, and implications for choosing a one-sided versus two-sided test. The p-value is defined and a discussion of controversies that have arisen over its use are included. After reading this chapter, the reader will have a better understanding of the necessary steps to set up a hypothesis test and make valid inference about the quantity of interest. Other topics in this chapter include exact hypothesis tests, which may be preferable for small sample settings, and the choice of a parametric versus nonparametric test. The chapter also includes a brief discussion of the implications of multiple comparisons on hypothesis testing and considerations of hypothesis testing in the setting of noninferiority trials.

Suggested Citation

  • Pamela A. Shaw & Michael A. Proschan, 2022. "Estimation and Hypothesis Testing," Springer Books, in: Steven Piantadosi & Curtis L. Meinert (ed.), Principles and Practice of Clinical Trials, chapter 83, pages 1615-1630, Springer.
    • Handle: RePEc:spr:sprchp:978-3-319-52636-2_114
    DOI: 10.1007/978-3-319-52636-2_114
    as

    Download full text from publisher

    To our knowledge, this item is not available for download. To find whether it is available, there are three options:
    1. Check below whether another version of this item is available online.
    2. Check on the provider's web page whether it is in fact available.
    3. Perform a
    for a similarly titled item that would be available.

    More about this item

    Keywords

    ;
    ;
    ;
    ;
    ;
    ;
    ;
    ;
    ;
    ;
    ;

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:spr:sprchp:978-3-319-52636-2_114. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.springer.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.