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Cell Cycle as an Object of Control

In: System Engineering Approach to Planning Anticancer Therapies

Author

Listed:
  • Andrzej Świerniak

    (Silesian University of Technology, Institute of Automatic Control)

  • Marek Kimmel

    (Silesian University of Technology, Institute of Automatic Control
    Rice University)

  • Jaroslaw Smieja

    (Silesian University of Technology, Institute of Automatic Control)

  • Krzysztof Puszynski

    (Silesian University of Technology, Institute of Automatic Control)

  • Krzysztof Psiuk-Maksymowicz

    (Silesian University of Technology, Institute of Automatic Control)

Abstract

This chapter is devoted to models of cancer growth and anticancer therapies that put special emphasis on the dependence of therapy efficiency on cell cycle. First, biological background is introduced and detailed description of a cell cycle is given, based on the review of biological literature. It is supplemented with information about chosen chemotherapeutic drugs and their efficacy with respect to the cell cycle. Next, pharmacokinetic and pharmacodynamics aspects of chemotherapeutics are briefly described. They along with cell cycle specificity of drugs may lead to various phenomena of resonances and aftereffects that need to be taken into account in therapy and synchronization of treatment protocols. These issues are mentioned in a separate section of this chapter. Finally, models that incorporate evolution of drug resistance are presented. For all models, the problem of finding a suitable treatment protocol is formulated as a problem of control optimization and some results of application of optimization theory to solve these problems are presented.

Suggested Citation

  • Andrzej Świerniak & Marek Kimmel & Jaroslaw Smieja & Krzysztof Puszynski & Krzysztof Psiuk-Maksymowicz, 2016. "Cell Cycle as an Object of Control," Springer Books, in: System Engineering Approach to Planning Anticancer Therapies, chapter 0, pages 9-54, Springer.
    • Handle: RePEc:spr:sprchp:978-3-319-28095-0_2
    DOI: 10.1007/978-3-319-28095-0_2
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