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Basic Exploratory Proteins Analysis with Statistical Methods Applied on Structural Features

In: Mathematical Models in Biology

Author

Listed:
  • Eugenio Del Prete

    (Institute of Food Science, National Research Council)

  • Serena Dotolo

    (Institute of Food Science, National Research Council)

  • Anna Marabotti

    (Institute of Food Science, National Research Council
    University of Salerno, Department of Chemistry and Biology)

  • Angelo Facchiano

    (Institute of Food Science, National Research Council)

Abstract

Exploratory Data Analysis (EDA) is an approach for summarizing and visualizing the important characteristics of a data set, in order to make a prearranged data screening and display multivariate data in a graphical way, to render them more comprehensible. Moreover, it reveals hidden aspects within the simple evaluations. In particular, EDA is suitable for datasets with comparable variables, as structural-geometrical protein features. In this work, we analyzed some proteins belonging to ten different architectural families. After retrieval, feature selection and normalization stages, the dataset has been processed by means of simple correlation, partial correlation and principal component analysis (PCA), highlighting family-independent or family-specific relationships, and possible outliers for the dataset itself. The results can be useful to connect these features to functional protein properties.

Suggested Citation

  • Eugenio Del Prete & Serena Dotolo & Anna Marabotti & Angelo Facchiano, 2015. "Basic Exploratory Proteins Analysis with Statistical Methods Applied on Structural Features," Springer Books, in: Valeria Zazzu & Maria Brigida Ferraro & Mario R. Guarracino (ed.), Mathematical Models in Biology, edition 1, pages 173-187, Springer.
    • Handle: RePEc:spr:sprchp:978-3-319-23497-7_13
    DOI: 10.1007/978-3-319-23497-7_13
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