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Focal Adhesion Kinase as a Cellular Mechano-Sensor

In: High Performance Computing in Science and Engineering ‘13

Author

Listed:
  • Jing Zhou

    (Heidelberg Institute for Theoretical Studies
    Max-Planck Institute for Intelligent Systems)

  • Agnieszka Bronowska

    (Heidelberg Institute for Theoretical Studies
    Max-Planck Institute for Intelligent Systems)

  • Bogdan Costescu

    (Heidelberg Institute for Theoretical Studies
    Max-Planck Institute for Intelligent Systems)

  • Frauke Graeter

    (Heidelberg Institute for Theoretical Studies
    Max-Planck Institute for Intelligent Systems)

Abstract

Focal adhesion kinase (FAK) is a component of focal adhesion sites, which plays a crucial role in cell differentiation and motility. Using molecular dynamic simulations, we observed that binding of the phospho-inositide phosphatidylinositol-4,5-bisphosphate ( $$\mathit{PIP}_{2}$$ ) by FAK can induce major conformational changes of FAK and exposure of its auto-phosphorylation site, but it cannot induce FAK’s activation. Our results support the biological experimental data by providing an atomic description of FAK’s conformational changes within FERM and kinase domains.

Suggested Citation

  • Jing Zhou & Agnieszka Bronowska & Bogdan Costescu & Frauke Graeter, 2013. "Focal Adhesion Kinase as a Cellular Mechano-Sensor," Springer Books, in: Wolfgang E. Nagel & Dietmar H. Kröner & Michael M. Resch (ed.), High Performance Computing in Science and Engineering ‘13, edition 127, pages 663-669, Springer.
    • Handle: RePEc:spr:sprchp:978-3-319-02165-2_46
    DOI: 10.1007/978-3-319-02165-2_46
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