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Privacy-Preserving Record Linkage for Real-World Data

In: Real-World Evidence in Medical Product Development

Author

Listed:
  • Tianyu Zhan

    (AbbVie Inc., Data and Statistical Sciences)

  • Yixin Fang

    (AbbVie Inc., Data and Statistical Sciences)

  • Weili He

    (AbbVie Inc., Data and Statistical Sciences)

Abstract

Real-world data (RWD) are data relating to health status and delivery of health care routinely collected from a variety of sources, including electronic health records (EHRs), claims activities, and patient registries. It is of great interest to aggregate and link data of the same patients from several data sources to provide a more comprehensive longitudinal evaluation of treatments from different aspects. Privacy-Preserving Record Linkage (PPRL) is a framework to match records from different datasets without compromising privacy and confidentiality of these entities. In this chapter, we review several aspects behind PPRL, including data preprocessing, privacy protection, linkage, and performance evaluation. We also provide a demonstration via an existing R package on NHANES (National Health and Nutrition Examination Survey).

Suggested Citation

  • Tianyu Zhan & Yixin Fang & Weili He, 2023. "Privacy-Preserving Record Linkage for Real-World Data," Springer Books, in: Weili He & Yixin Fang & Hongwei Wang (ed.), Real-World Evidence in Medical Product Development, pages 109-122, Springer.
  • Handle: RePEc:spr:sprchp:978-3-031-26328-6_7
    DOI: 10.1007/978-3-031-26328-6_7
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