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Modelling Therapeutic Vaccines

In: Trends in Biomathematics: Modeling Cells, Flows, Epidemics, and the Environment

Author

Listed:
  • Elaheh Abdollahi

    (York University, Agent-Based Modelling Laboratory)

  • Affan Shoukat

    (Yale School of Public Health, Center for Infectious Disease Modeling and Analysis)

  • Seyed M. Moghadas

    (York University, Agent-Based Modelling Laboratory)

Abstract

Prophylactic vaccines have dramatically reduced the worldwide burden of many vaccine-preventable diseases. However, several diseases, including cancer, autoimmune diseases, Alzheimer’s, and some infectious diseases, continue to cause significant morbidity, mortality, and socioeconomic upheavals. Therapeutic vaccines in clinical development appear promising in curbing the burden of such diseases. The projected number of therapeutic vaccines in the current pipeline highlights the need for, and importance of, systematic and targeted efforts to assess the impact of these vaccines. Mathematical and computational modelling has proven a powerful tool for evaluating the outcomes of vaccination and projecting short- and long-term disease dynamics. In this work, we describe the role of modelling in the context of therapeutic vaccines and develop simple models for three infectious diseases (i.e., Herpes simplex virus—type 2, Clostridium difficile infection, and Tuberculosis) to illustrate their potential for vaccine evaluation in future studies.

Suggested Citation

  • Elaheh Abdollahi & Affan Shoukat & Seyed M. Moghadas, 2020. "Modelling Therapeutic Vaccines," Springer Books, in: Rubem P. Mondaini (ed.), Trends in Biomathematics: Modeling Cells, Flows, Epidemics, and the Environment, pages 381-394, Springer.
    • Handle: RePEc:spr:sprchp:978-3-030-46306-9_23
    DOI: 10.1007/978-3-030-46306-9_23
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