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Application of Cox Regression with a Change Point in Clinical Studies

In: Lifetime Data: Models in Reliability and Survival Analysis

Author

Listed:
  • Xiaolong Luo

    (St. Jude Children’s Research Hospital, Department of Biostatistics)

  • Gang Chen

    (St. Jude Children’s Research Hospital, Department of Biostatistics)

  • James M. Boyett

    (St. Jude Children’s Research Hospital, Department of Biostatistics)

Abstract

Cox regression with an unknown change point and the corresponding large sample theory are discussed. We show how the results of this approach can be applied to computer-simulated data and to failure-time data from a large cohort of children treated at St. Jude Children’s Research Hospital for newly diagnosied acute lymphoblastic leukemia.

Suggested Citation

  • Xiaolong Luo & Gang Chen & James M. Boyett, 1996. "Application of Cox Regression with a Change Point in Clinical Studies," Springer Books, in: Nicholas P. Jewell & Alan C. Kimber & Mei-Ling Ting Lee & G. A. Whitmore (ed.), Lifetime Data: Models in Reliability and Survival Analysis, pages 213-217, Springer.
    • Handle: RePEc:spr:sprchp:978-1-4757-5654-8_28
    DOI: 10.1007/978-1-4757-5654-8_28
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