IDEAS home Printed from https://ideas.repec.org/h/spr/sprchp/978-1-4684-4037-9_4.html
   My bibliography  Save this book chapter

The Role of Tubulin in Steroidogenesis of Mouse Adrenal Y-1 Cells and Rat Leydig CCL 43 Cells

In: Cell and Muscle Motility

Author

Listed:
  • Mike A. Clark

    (The University of Texas Health Science Center at Dallas, Department of Cell Biology)

  • Jerry W. Shay

    (The University of Texas Health Science Center at Dallas, Department of Cell Biology)

Abstract

The mechanisms of adrenocorticotropic hormone (ACTH)-induced steroid secretion in the adrenal cortex have not been clearly elucidated. However, it has been demonstrated that ACTH acts in the regulation of the steroidogenic pathway by controlling the conversion of cholesterol into pregnenolone. Cellular-fractionation studies have demonstrated that the enzymes necessary for this conversion are located in the mitochondria, whereas the cholesterol is stored in the cytoplasm. Kowal (1970) demonstrated that all the enzymes necessary to synthesize steroids are present prior to ACTH stimulation, and he concluded that steroidogenesis was regulated by controlling the transport of cholesterol to the mitochondria. Temple and Wolff (1973) showed that colchicine, and other drugs that depolymerize microtubules, could induce steroidogenesis independent of ACTH, and from these data they hypothesized that microtubules prevented the transport of cholesterol to the mitochondria and that the mechanism of ACTH-induced steroidogenesis involved the removal of this restriction.

Suggested Citation

  • Mike A. Clark & Jerry W. Shay, 1982. "The Role of Tubulin in Steroidogenesis of Mouse Adrenal Y-1 Cells and Rat Leydig CCL 43 Cells," Springer Books, in: Robert M. Dowben & Jerry W. Shay (ed.), Cell and Muscle Motility, chapter 4, pages 53-61, Springer.
    • Handle: RePEc:spr:sprchp:978-1-4684-4037-9_4
    DOI: 10.1007/978-1-4684-4037-9_4
    as

    Download full text from publisher

    To our knowledge, this item is not available for download. To find whether it is available, there are three options:
    1. Check below whether another version of this item is available online.
    2. Check on the provider's web page whether it is in fact available.
    3. Perform a
    for a similarly titled item that would be available.

    More about this item

    Keywords

    ;
    ;
    ;
    ;
    ;

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:spr:sprchp:978-1-4684-4037-9_4. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.springer.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.