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Myosin Flexibility

In: Cell and Muscle Motility

Author

Listed:
  • Stephen C. Harvey

    (University of Alabama in Birmingham, Biophysics Section, Department of Biomathematics)

  • Herbert C. Cheung

    (University of Alabama in Birmingham, Biophysics Section, Department of Biomathematics)

Abstract

The description of the molecular events that produce tension in a contracting muscle is often called mechanochemistry, a term that well describes the synthesis of the two key elements in the contractile cycle. One of those elements is mechanical: we need to be able to describe in detail, with resolution down to the atomic level, the sequence of conformational changes that cause the thick and thin filaments to slide past one another. The other element is chemical: we need to determine the sequence of biochemical reactions in the contractile cycle and to measure the energetic and kinetic parameters of each of those reactions. Finally, the problem requires synthesis: we need to explain the coupling of the mechanical and chemical events. Only then will we understand how the chemical energy released by the hydrolysis of ATP is converted to the mechanical work performed by the contracting muscle.

Suggested Citation

  • Stephen C. Harvey & Herbert C. Cheung, 1982. "Myosin Flexibility," Springer Books, in: Robert M. Dowben & Jerry W. Shay (ed.), Cell and Muscle Motility, chapter 20, pages 279-302, Springer.
    • Handle: RePEc:spr:sprchp:978-1-4684-4037-9_20
    DOI: 10.1007/978-1-4684-4037-9_20
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