IDEAS home Printed from https://ideas.repec.org/h/spr/sprchp/978-1-4684-4037-9_18.html
   My bibliography  Save this book chapter

The Regulation of Cardiac-Muscle Contraction by Troponin

In: Cell and Muscle Motility

Author

Listed:
  • James D. Potter

    (University of Cincinnati College of Medicine, Section of Contractile Proteins, Department of Pharmacology and Cell Biophysics)

  • Michael J. Holroyde

    (University of Cincinnati College of Medicine, Department of Physiology)

  • Steven P. Robertson

    (University of Cincinnati College of Medicine, Section of Contractile Proteins, Department of Pharmacology and Cell Biophysics)

  • R. John Solaro

    (University of Cincinnati College of Medicine, Department of Physiology and Department of Pharmacology and Cell Biophysics)

  • Evangelia G. Kranias

    (University of Cincinnati College of Medicine, Section of Contractile Proteins, Department of Pharmacology and Cell Biophysics)

  • J. David Johnson

    (University of Cincinnati College of Medicine, Section of Contractile Proteins, Department of Pharmacology and Cell Biophysics)

Abstract

The purpose of this review is to summarize the work we have done over the past several years regarding the regulation of cardiac muscle contraction by troponin (Tn). Studies have been carried out on the Ca2+-binding properties of cardiac Tn (the 1:1:1 molar-ratio complex of TnC, the Ca2+-binding subunit; TnI, the inhibitory subunit; and TnT, the tropomyosin-binding subunit) and TnC, and the effects of Mg2+ and phosphorylation on these parameters have been measured. The relationship between these parameters and the activation of myofibrillar ATPase in cardiac and skeletal muscle will be discussed and related to the known physiological properties of cardiac muscle in different contractile states (e.g., ³-adrenergic stimulation). Since the binding of Ca2+ to Tn is only the first step in the activation of muscle contraction, studies on Ca2+-induced alterations in the interactions of Tn subunits, tropomyosin (Tm), and actin required to bring about muscle contraction or relaxation will also be discussed.

Suggested Citation

  • James D. Potter & Michael J. Holroyde & Steven P. Robertson & R. John Solaro & Evangelia G. Kranias & J. David Johnson, 1982. "The Regulation of Cardiac-Muscle Contraction by Troponin," Springer Books, in: Robert M. Dowben & Jerry W. Shay (ed.), Cell and Muscle Motility, chapter 18, pages 245-255, Springer.
    • Handle: RePEc:spr:sprchp:978-1-4684-4037-9_18
    DOI: 10.1007/978-1-4684-4037-9_18
    as

    Download full text from publisher

    To our knowledge, this item is not available for download. To find whether it is available, there are three options:
    1. Check below whether another version of this item is available online.
    2. Check on the provider's web page whether it is in fact available.
    3. Perform a
    for a similarly titled item that would be available.

    More about this item

    Keywords

    ;
    ;
    ;
    ;
    ;

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:spr:sprchp:978-1-4684-4037-9_18. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.springer.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.