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Participant Adherence

In: Fundamentals of Clinical Trials

Author

Listed:
  • Lawrence M. Friedman

  • Curt D. Furberg

    (Wake Forest University, School of Medicine)

  • David L. DeMets

    (University of Wisconsin, Department of Biostatistics & Medical Informatics)

Abstract

The terms compliance and adherence are often used interchangeably. Compliance is defined as “the extent to which a person’s behavior (in terms of taking medications, following diets, or executing lifestyle changes) coincides with medical or health advice” [1]. The term adherence is defined similarly, but implies active participant involvement. This book uses the term adherence. For example, an adherer is a participant who meets the standards of adherence as established by the investigator. In a drug trial, he may be a participant who takes at least a predetermined amount such as 80% of the protocol dose. There should also be a maximum dose that defines adherence. This dose will depend on the nature of the drug being evaluated (no more than 100% for some, perhaps a bit higher for others). A review of 192 clinical trial publications from high-impact journals reveals important variability in the definition (and reporting) of medication adherence [2].

Suggested Citation

  • Lawrence M. Friedman & Curt D. Furberg & David L. DeMets, 2010. "Participant Adherence," Springer Books, in: Fundamentals of Clinical Trials, edition 0, chapter 0, pages 251-268, Springer.
    • Handle: RePEc:spr:sprchp:978-1-4419-1586-3_14
    DOI: 10.1007/978-1-4419-1586-3_14
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