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Equivalence Testing

In: Statistics Applied to Clinical Trials

Author

Listed:
  • Ton J. Cleophas

    (European Interuniversity College of Pharmaceutical Medicine Lyon
    Albert Schweitzer Hospital, Department Medicine)

  • Aeilko H. Zwinderman

    (Academic Medical Center Amsterdam, Department Biostatistics and Epidemiology)

  • Toine F. Cleophas

    (Technical University)

Abstract

A study unable to find a difference is not the same as an equivalent study. For example, a study of 3 subjects does not find a significant difference simply because the sample size is too small. Equivalence testing is particularly important for studying the treatment of diseases for which a placebo control would unethical. In the situation a new treatment must be compared with standard treatment. The latter comparison is at risk of finding little differences.

Suggested Citation

  • Ton J. Cleophas & Aeilko H. Zwinderman & Toine F. Cleophas, 2006. "Equivalence Testing," Springer Books, in: Statistics Applied to Clinical Trials, chapter 0, pages 59-65, Springer.
    • Handle: RePEc:spr:sprchp:978-1-4020-4650-6_4
    DOI: 10.1007/978-1-4020-4650-6_4
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