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Inference of Protein Function from the Structure of Interaction Networks

In: Structural Analysis of Complex Networks

Author

Listed:
  • Oliver Mason

    (NUI Maynooth, Hamilton Institute)

  • Mark Verwoerd
  • Peter Clifford

Abstract

We consider the problem of using graph-theoretical techniques to predict the function of unannotated proteins in an organism’s proteome. Specifically, we present an overview of the major methods for predicting protein function based on interaction network structure and describe an abstract framework within which these methods can be treated in a unified fashion. We also present a comparison of the proposed methods and highlight some open theoretical and practical questions in the area.

Suggested Citation

  • Oliver Mason & Mark Verwoerd & Peter Clifford, 2011. "Inference of Protein Function from the Structure of Interaction Networks," Springer Books, in: Matthias Dehmer (ed.), Structural Analysis of Complex Networks, chapter 0, pages 439-461, Springer.
    • Handle: RePEc:spr:sprchp:978-0-8176-4789-6_18
    DOI: 10.1007/978-0-8176-4789-6_18
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