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Assessing Possible Late Treatment Effects Early: The Diabetic Retinopathy Study Experience

In: Data Monitoring in Clinical Trials

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  • Fred Ederer

Abstract

The Diabetic Retinopathy Study (DRS) assessed the ability of photocoagulation to delay or prevent severe visual loss in people with proliferative diabetic retinopathy. Benefit was detected early, but there where concerns about the possibility of late adverse effects. Calculations using projected blindness and death rates reassured the data monitoring committee that even large late adverse affects would not offset the early benefit already observed.

Suggested Citation

  • Fred Ederer, 2006. "Assessing Possible Late Treatment Effects Early: The Diabetic Retinopathy Study Experience," Springer Books, in: David L. DeMets & Curt D. Furberg & Lawrence M. Friedman (ed.), Data Monitoring in Clinical Trials, chapter 0, pages 55-63, Springer.
    • Handle: RePEc:spr:sprchp:978-0-387-30107-5_5
    DOI: 10.1007/0-387-30107-0_5
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