IDEAS home Printed from https://ideas.repec.org/h/spr/sprchp/978-0-387-30107-5_35.html
   My bibliography  Save this book chapter

Making Independence Work: Monitoring the Bevacizumab Colorectal Cancer Clinical Trial

In: Data Monitoring in Clinical Trials

Author

Listed:
  • Janet Wittes

    (Statistics Collaborative)

  • Eric Holmgren

    (Genentech Inc.)

  • Heidi Christ-Schmidt

    (Statistics Collaborative)

  • Alex Bajamonde

    (Genentech Inc.)

Abstract

Genentech’s phase III study of colorectal cancer aimed to show that administration of bevacizumab, its recombinant human anti-vascular endothelial growth factor antibody, to patients with metastatic colorectal cancer would reduce mortality. The four-member DMC was responsible for reviewing real-time safety data, selecting the experimental arm of the study at an interim analysis, and assessing efficacy at a second interim analysis. Genentech and the entire study team remained blinded to treatment allocation during the course of the trial. The study, which proceeded to its planned end, showed an estimated hazard ratio for death of 0.66 (p

Suggested Citation

  • Janet Wittes & Eric Holmgren & Heidi Christ-Schmidt & Alex Bajamonde, 2006. "Making Independence Work: Monitoring the Bevacizumab Colorectal Cancer Clinical Trial," Springer Books, in: David L. DeMets & Curt D. Furberg & Lawrence M. Friedman (ed.), Data Monitoring in Clinical Trials, chapter 0, pages 360-367, Springer.
    • Handle: RePEc:spr:sprchp:978-0-387-30107-5_35
    DOI: 10.1007/0-387-30107-0_35
    as

    Download full text from publisher

    To our knowledge, this item is not available for download. To find whether it is available, there are three options:
    1. Check below whether another version of this item is available online.
    2. Check on the provider's web page whether it is in fact available.
    3. Perform a
    for a similarly titled item that would be available.

    More about this item

    Keywords

    ;
    ;
    ;
    ;
    ;

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:spr:sprchp:978-0-387-30107-5_35. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.springer.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.