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Nonparametric Frequency Detection and Optimal Coding in Molecular Biology

In: Modeling Uncertainty

Author

Listed:
  • David S. Stoffer

    (University of Pittsburgh)

Abstract

The concept of spectral envelope for analyzing periodicities in categorical-valued time series was introduced in the statistics literature as a computationally simple and general statistical methodology for the harmonic analysis and scaling of non-numeric sequences. One benefit of this technique is that it combines nonparametric statistical analysis with modern computer power to quickly search for diagnostic patterns within long sequences. An interesting area of application is the nucleosome positioning signals and optimal alphabets in long DNA sequences. The examples focus on period lengths in nucleosome signals and optimal alphabets in herpesviruses and we point out some inconsistencies in established gene segments.

Suggested Citation

  • David S. Stoffer, 2002. "Nonparametric Frequency Detection and Optimal Coding in Molecular Biology," International Series in Operations Research & Management Science, in: Moshe Dror & Pierre L’Ecuyer & Ferenc Szidarovszky (ed.), Modeling Uncertainty, chapter 0, pages 129-154, Springer.
    • Handle: RePEc:spr:isochp:978-0-306-48102-4_7
    DOI: 10.1007/0-306-48102-2_7
    as

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