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TITEBETA: Stata module to conduct toxicity monitoring for phase 2 (and 3) trials

Author

Listed:
  • E. Paul Wileyto

    (University of Pennsylvania)

Programming Language

Stata

Abstract

titebeta is a routine for safety monitoring of late onset toxicities in phase 2 (and 3) clinical trials. It calculates the posterior probability that the toxicity event rate exceeds a limit, based on censored data for toxicities and a beta prior. Data are entered as a list of two variables, with the first depvar being a 0/1 toxicity outcome, and the second {indepvar} being an elapsed time variable. The calculation uses the weighting scheme described by Cheung & Thall (Biometrics, 2002), for the simple case that considers only toxicity monitoring, and not complex trial outcomes.

Suggested Citation

  • E. Paul Wileyto, 2023. "TITEBETA: Stata module to conduct toxicity monitoring for phase 2 (and 3) trials," Statistical Software Components S459217, Boston College Department of Economics.
    • Handle: RePEc:boc:bocode:s459217
    Note: This module should be installed from within Stata by typing "ssc install titebeta". The module is made available under terms of the GPL v3 (https://www.gnu.org/licenses/gpl-3.0.txt). Windows users should not attempt to download these files with a web browser.
    as

    Download full text from publisher

    File URL: http://fmwww.bc.edu/repec/bocode/t/titebeta.ado
    File Function: program code
    Download Restriction: no
    File URL: http://fmwww.bc.edu/repec/bocode/t/titebeta.sthlp
    File Function: help file
    Download Restriction: no
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