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SIZE AND SURFACE EFFECT OF GOLD NANOPARTICLES(AuNPs)IN NANOGOLD-ASSISTED PCR

Author

Listed:
  • JIEHUAN HUANG

    (College of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, P. R. China)

  • XIAODONG ZHANG

    (Shanghai Institute of Applied Physics, Chinese Academy of Sciences, P.O. Box 800-204, Shanghai 201800, P. R. China)

  • CHUNMEI WANG

    (College of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, P. R. China)

  • LIHUA WANG

    (Shanghai Institute of Applied Physics, Chinese Academy of Sciences, P.O. Box 800-204, Shanghai 201800, P. R. China)

  • HAIKUO LI

    (College of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, P. R. China)

  • XUEYAN CAO

    (College of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, P. R. China)

  • AILI ZHANG

    (College of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, P. R. China)

  • XUELING LI

    (College of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, P. R. China)

  • CHUNHAI FAN

    (College of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, P. R. China;
    Shanghai Institute of Applied Physics, Chinese Academy of Sciences, P.O. Box 800-204, Shanghai 201800, P. R. China)

  • JUN HU

    (College of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, P. R. China;
    Shanghai Institute of Applied Physics, Chinese Academy of Sciences, P.O. Box 800-204, Shanghai 201800, P. R. China)

Abstract

Recently, gold nanoparticles(AuNPs)were reported to increase the specificity and efficiency of the polymerase chain reaction (PCR). In this paper, we tested the enhancement ofAuNPswith five different sizes on the specificity of two-round PCR. The results showed that, except 5.02 nmAuNPs, theAuNPsthat could achieve the similar enhancement happened to have nearly the same total surface area. The surface effect seems to be the key factor of nanogold-assisted PCR.

Suggested Citation

  • Jiehuan Huang & Xiaodong Zhang & Chunmei Wang & Lihua Wang & Haikuo Li & Xueyan Cao & Aili Zhang & Xueling Li & Chunhai Fan & Jun Hu, 2008. "SIZE AND SURFACE EFFECT OF GOLD NANOPARTICLES(AuNPs)IN NANOGOLD-ASSISTED PCR," Surface Review and Letters (SRL), World Scientific Publishing Co. Pte. Ltd., vol. 15(06), pages 757-762.
    • Handle: RePEc:wsi:srlxxx:v:15:y:2008:i:06:n:s0218625x08012189
    DOI: 10.1142/S0218625X08012189
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