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Polymer Microspheres With Permanent Antibacterial Surface From Surface-Initiated Atom Transfer Radical Polymerization Of 4-Vinylpyridine And Quaternization

Author

Listed:
  • ZHENPING CHENG

    (School of Chemistry and Chemical Engineering, Suzhou University, Suzhou, 215006, P. R. China)

  • XIULIN ZHU

    (School of Chemistry and Chemical Engineering, Suzhou University, Suzhou, 215006, P. R. China)

  • Z. L. SHI

    (Department of Chemical and Biomolecular Engineering, National University of Singapore, Kent Ridge, Singapore 119260, Singapore)

  • K. G. NEOH

    (Department of Chemical and Biomolecular Engineering, National University of Singapore, Kent Ridge, Singapore 119260, Singapore)

  • E. T. KANG

    (Department of Chemical and Biomolecular Engineering, National University of Singapore, Kent Ridge, Singapore 119260, Singapore)

Abstract

Crosslinked poly(4-vinylbenzyl chloride) (PVBC) microspheres of about 550 μm in diameter were first synthesized by suspension copolymerization of 4-vinylbenzyl chloride (VBC) in the presence of a crosslinking agent, ethylene glycol dimethacrylate (EGDMA). Subsequent surface-initiated atom transfer radical polymerization (ATRP) of 4-vinylpyridine (4VP), using the VBC units of PVBC on the microsphere surface as the macroinitiators, produced well-defined (nearly monodisperse) and covalently tethered poly(4-vinylpyridine) (P4VP) brushes. Quaternization of the tertiary amine groups of the P4VP brushes with hexyl bromide gave rise to a high concentration of quaternary ammonium salt (QAS) on the microsphere surfaces. The chemical composition of the microsphere surfaces at various stages of surface modification was characterized by X-ray photoelectron spectroscopy (XPS). The bactericidal effect of the QAS-functionalized microspheres onEscherichia coli (E. coli)was demonstrated. No significant loss in the surface bactericidal activity of the microsphere was observed during repeated applications.

Suggested Citation

  • Zhenping Cheng & Xiulin Zhu & Z. L. Shi & K. G. Neoh & E. T. Kang, 2006. "Polymer Microspheres With Permanent Antibacterial Surface From Surface-Initiated Atom Transfer Radical Polymerization Of 4-Vinylpyridine And Quaternization," Surface Review and Letters (SRL), World Scientific Publishing Co. Pte. Ltd., vol. 13(02n03), pages 313-318.
    • Handle: RePEc:wsi:srlxxx:v:13:y:2006:i:02n03:n:s0218625x06008220
    DOI: 10.1142/S0218625X06008220
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