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Monte Carlo Simulations Of The Inside Intron Recombination

Author

Listed:
  • STANISŁAW CEBRAT

    (Department of Genomics, Wrocław University, ul. Przybyszewskiego 63/77, 51-148 Wrocław, Poland)

  • ANDRZEJ PȨKALSKI

    (Institute of Theoretical Physics, Wrocław University, pl. Maxa Borna 9, 50-204 Wrocław, Poland)

  • FABIAN SCHARF

    (Institute of Theoretical Physics, Cologne University, D-50923 Cologne, Germany)

Abstract

Biological genomes are divided into coding and non-coding regions. Introns are non-coding parts within genes, while the remaining non-coding parts are intergenic sequences. To study evolutionary significance of the inside intron recombination we have used two models based on the Monte Carlo method. In our computer simulations we have implemented the internal structure of genes by declaring the probability of recombination between exons. One situation when inside intron recombination is advantageous is recovering functional genes by combining proper exons dispersed in the genetic pool of the population after a long period without selection for the function of the gene. Populations have to pass through the bottleneck, then. These events are rather rare and we have expected that there should be other phenomena giving profits from the inside intron recombination. In fact we have found that inside intron recombination is advantageous only in the case when after recombination, besides the recombinant forms, parental haplotypes are available and selection is set already on gametes.

Suggested Citation

  • Stanisław Cebrat & Andrzej Pȩkalski & Fabian Scharf, 2006. "Monte Carlo Simulations Of The Inside Intron Recombination," International Journal of Modern Physics C (IJMPC), World Scientific Publishing Co. Pte. Ltd., vol. 17(02), pages 305-314.
    • Handle: RePEc:wsi:ijmpcx:v:17:y:2006:i:02:n:s0129183106008984
    DOI: 10.1142/S0129183106008984
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