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Neutral Networks Of Interacting Rna Secondary Structures

Author

Listed:
  • CAMILLE STEPHAN-OTTO ATTOLINI

    (Institut für Theoretische Chemie, Universität Wien, Währingerstraße 17, A-1090 Wien, Austria)

  • PETER F. STADLER

    (Lehrstuhl für Bioinformatik, Institut für Informatik, Universität Leipzig, Kreuzstraße 7a, D-04103 Leipzig, Germany;
    Institut für Theoretische Chemie, Universität Wien, Währingerstraße 17, A-1090 Wien, Austria;
    The Santa Fe Institute, 1399 Hyde Park Rd., Santa Fe NM 87501, USA)

Abstract

RNA molecules interact by forming inter-molecular base pairs that compete with the intra-molecular base pairs of their secondary structures. We investigate the patterns of neutral mutations in RNAs whose function is the interaction with other RNAs, i.e. theco-foldingwith one or more other RNA molecules. We find that (i) the degree of neutrality is much smaller in interacting RNAs compared to RNAs that just have to coform to a single externally prescribed target structure, and (ii) strengthening this contraint to the conservation of the co-folded structure with two or more partners essentially eliminates neutrality. It follows that RNAs whose function depends on the formation of a specific interaction complex with a target RNA molecule will evolve much more slowly than RNAs with a function depending only on their own structure.

Suggested Citation

  • Camille Stephan-Otto Attolini & Peter F. Stadler, 2005. "Neutral Networks Of Interacting Rna Secondary Structures," Advances in Complex Systems (ACS), World Scientific Publishing Co. Pte. Ltd., vol. 8(02n03), pages 275-283.
    • Handle: RePEc:wsi:acsxxx:v:08:y:2005:i:02n03:n:s0219525905000427
    DOI: 10.1142/S0219525905000427
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